Results 141 to 150 of about 5,179,156 (340)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Patient safety culture and associated factors in secondary health care of the Capital Region of Denmark: influence of specialty, healthcare profession and gender. [PDF]

BMJ Open Qual, 2022
Østergaard D, Madsen MD, Ersbøll AK, Frappart HS, Kure JH, Kristensen S.   +5 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Comprehensive Medication Management: Implications for the Patient and Pharmacist [PDF]

, 2017
Since 1979, state pharmacy practice laws have begun to allow pharmacists to provide advanced levels of care in collaboration with prescribers. These might be termed medication therapy management, collaborative practice, comprehensive medication ...
Brayer, Hayden, Bunting, Barry, DeLucenay, Alexander, Williams, Karl   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Researching Health Care Management Using Secondary Data

, 2019
Aimsa) To highlight gaps in the extant research on the characteristics and impact of managers in healthcare.b) To define and provide a taxonomy of administrative data sources relevant to researching healthcare management.c) To review the range of statistical techniques used to analyse administrative data.d) To illustrate how the analysis of ...
Ian Kirkpatrick, Gianluca Veronesi
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Informações da atenção secundária em Odontologia para avaliação dos modelos de atenção à saúde

Revista de Odontologia da UNESP
INTRODUÇÃO: Considerando-se o princípio da integralidade e a construção das redes de atenção no Sistema Único de Saúde, a atenção secundária pode refletir a resolutividade da atenção básica, apoiando a organização das ações e dos serviços de saúde bucal ...
Jaqueline Vilela Bulgareli, Eduardo Tanajura de Faria, Gláucia Maria Bovi Ambrosano, Fabiana de Lima Vazquez, Karine Laura Cortellazzi, Marcelo de Castro Meneghim, Fábio Luiz Mialhe, Antonio Carlos Pereira   +7 more
doaj  

Access to primary and secondary health care services for people living with diabetes and lower-limb amputation during the COVID-19 pandemic in Lebanon: a qualitative study. [PDF]

BMC Health Serv Res, 2022
Chaiban L, Benyaich A, Yaacoub S, Rawi H, Truppa C, Bardus M.   +5 more
europepmc   +1 more source

Mental health and addiction credential in primary care [PDF]

This report is an evaluation of a demonstration coordinated by Health Workforce New Zealand. The credential aims to recognise and boost the skills and knowledge of registered nurses who work with patients with mental health and addiction needs ...

core