Results 91 to 100 of about 2,760,769 (327)

Bone Health Following Lifestyle‐Induced Weight Loss in Individuals With Overweight/Obesity: A Narrative Review

Obesity, EarlyView.
ABSTRACT Although weight loss has many health benefits for people with overweight/obesity, its potential negative impact on bone health needs to be considered. This review provides a comprehensive overview of the effects of intentional weight loss achieved by lifestyle changes on bone health outcomes in adults with overweight/obesity and discusses ...
Mélanie A. Legrand, Julien Paccou, Jean‐Michel Lecerf, Thierry Thomas, Roland Chapurlat, Bernard Cortet, Emmanuel Biver, Maria Papageorgiou   +7 more
wiley   +1 more source

Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease

Scientific Reports, 2017
Secondary hyperparathyroidism, in which parathyroid hormone (PTH) is excessively secreted in response to factors such as hyperphosphataemia, hypocalcaemia, and low 1,25-dihydroxyvitamin D (1,25(OH)2D) levels, is commonly observed in patients with chronic
K. Kawakami, Ai Takeshita, Kenryo Furushima, M. Miyajima, I. Hatamura, M. Kuro-o, Y. Furuta, K. Sakaguchi   +7 more
semanticscholar   +1 more source

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source

Objective assessment of functional and motor-cognitive outcomes among asymptomatic primary hyperparathyroidism patients undergoing parathyroidectomy using wearable technologies: a pilot study towards better informed clinical decision-making [PDF]

, 2017
For the past 40 years, most patients with Primary Hyperparathyroidism (PHPT) have presented with the asymptomatic form of PHPT. Despite the dominance of the asymptomatic PHPT phenotype, current National Institutes of Health (NIH) indications for ...
Siddiqi, Noreen
core  

Advantages of total parathyroidectomy in patients with secondary hyperparathyroidism induced by end stage renal disease

Frontiers in Endocrinology, 2023
IntroductionSecondary hyperparathyroidism, as a result of chronic kidney disease could be treated medically or surgically. When pharmacotherapy fails, patients undergo surgery - parathyroidectomy, the curative treatment of secondary hyperparathyroidism ...
Cristian Iorga, Cristian Iorga, Cristina Raluca Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Iuliana Andreiana, Iustinian Bengulescu, Iustinian Bengulescu, Traian Constantin, Traian Constantin, Victor Strambu, Victor Strambu   +11 more
doaj   +1 more source

Secondary Hyperparathyroidism: Pathophysiology and Treatment [PDF]

The Journal of the American Board of Family Medicine, 2009
Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients.
Wissam Saliba, Boutros El-Haddad
openaire   +3 more sources

Deciphering epigenetic regulation in postmenopausal osteoporosis: Current and future perspectives

VIEW, EarlyView.
In this perspective, the significant roles of microRNAs, long noncoding RNAs and circular RNAs in postmenopausal osteoporosis are thoroughly expounded. The advantages and limitations of typical noncoding RNAs as diagnostic biomarkers and therapeutic targets are summarized and discussed.
Xiumei Tang, Meiru Chen, Guixuan Xu, Yuan Li, Sen Guo, Yufeng Huang, Zhaoliang Hou, Xiaoling Hou, Zhijian Wei, Wenzhao Wang, Bing Ning   +10 more
wiley   +1 more source

Modified percutaneous ethanol injection of parathyroid adenoma in primary hyperparathyroidism. [PDF]

, 2008
Surgery is the treatment of choice for symptomatic primary hyperparathyroidism; unlikely few patients do not meet established surgical criteria or have comorbid conditions that prohibit surgery. In these subjects, medical therapy alone offers little hope
AGABITI ROSEI E, AGOSTI B, CAPPELLI C, CASTELLANO M, DE MARTINO E, DELBARBA A, GANDOSSI E, PELIZZARI G, PIROLA I   +8 more
core   +1 more source

Spasmodic Dysphonia

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Evaluation of a Phosphate Management Protocol to Achieve Optimum Serum Phosphate Levels in Hemodialysis Patients [PDF]

, 2008
Original article can be found at: http://www.sciencedirect.com/science/journal/10512276 Copyright National Kidney Foundation, Inc. DOI: 10.1053/j.jrn.2008.05.003To evaluate the effectiveness of a protocol designed to optimize serum phosphate levels in ...
Cheung, C.F., Cunningham, J., Fan, S., Glass, G., Madden, A.M., Yokum, D.   +5 more
core   +1 more source