Results 161 to 170 of about 3,879,257 (291)

Adrenocortical Carcinoma as an Atypical Cause of Secondary Hypertension. [PDF]

Kans J Med, 2023
Ogundare J, Meyer M, Al-Kasspooles M.
europepmc   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Mechanism-defined secondary hypertension enables precision diagnosis and treatment: an evidence review. [PDF]

Front Cardiovasc Med
Choudhary AK, Hait A, Baladaniya M.
europepmc   +1 more source

A case of pediatric secondary hypertension caused by juxtaglomerular cell tumor. [PDF]

Quant Imaging Med Surg, 2023
Ruan Y, Lian F, Tian Y, Li Q, Huang X.
europepmc   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Primary hyperaldosteronism in patient with Bardet-Biedl syndrome: unmasking secondary hypertension. [PDF]

Endocrinol Diabetes Metab Case Rep
Marinova E, Stoyanova L, Todorova T, Dimova M.   +3 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Barriers for Secondary Hypertension Screening in the United States: A National Physician Survey. [PDF]

J Am Heart Assoc
Turcu AF, Salman Z, Kromm SM, Zhang L, Zhao L, Suzer-Gurtekin ZT, Vincent G, Papaleontiou M.   +7 more
europepmc   +1 more source

Blood pressure and its correlates in children and adolescents in urban Nigeria [PDF]

Background: A substantial increase in the incidence of chronic non-communicable diseases (NCDs) and a decline in communicable diseases and poverty-related diseases are occurring in developing countries (including Nigeria) as a result of an ...
Ogboye, Oluwatoyin
core  

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source