Results 81 to 90 of about 3,879,257 (291)

Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model [PDF]

, 2010
Introduction Intra-abdominal hypertension is common in critically ill patients and is associated with increased morbidity and mortality. The optimal ventilation strategy remains unclear in these patients.
Brigit Roberts, Bill Noffsinger, Musk, Gabrielle C, Bhajan Singh, Hockings, Lisen E, Peter V van Heerden, Noffsinger, B., Lisen E Hockings, Regli, Adrian, van Heerden, Peter V, Singh, Bhajan, Singh, B., Roberts, B., Noffsinger, Bill, Regli, A., Gabrielle C Musk, Adrian Regli, Hockings, L.E., Musk, G.C., van Heerden, P.V., Roberts, Brigit   +20 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Non-pharmacological management of hypertension [PDF]

The importance of a healthy lifestyle is well understood for the primary and secondary prevention of cardiovascular disease. Numerous studies have emphasised the importance of lifestyle changes as an integral component of lowering blood pressure in both ...
Buckley, BJR, Finnie, SJ
core   +2 more sources

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors

Frontiers in Genetics
This report presents a case involving a young female patient diagnosed with von Hippel-Lindau (VHL) syndrome. The patient developed multiple sequential tumors, including spinal cord hemangioblastoma, multiple pancreatic cysts, and pheochromocytoma. Whole-
Jingyuan Li, Yun Ti, Xiao Yang, Keqiang Yan, Tongshuai Chen, Tao Guo, Qin Hu, Cheng Zhang, Peili Bu   +8 more
doaj   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Monogenic hypertension — state-of-the-art knowledge

Arterial Hypertension
Arterial hypertension is a severe public health problem. Due to a sedentary lifestyle and the obesity epidemic, the prevalence of primary arterial hypertension increases every year. However, the presence of secondary hypertension should not be overlooked.
Aleksandra Ostrowska-Czyżewska, Dominika Szwed, Joanna Barcińska   +2 more
doaj   +1 more source

Multivariable logistic regression for hypertension and untreated hypertension status by primary and secondary care accessibility.

, 2019
Multivariable logistic regression for hypertension and untreated hypertension status by primary and secondary care accessibility.
Tsunetaka Kijima (818250), Toru Nabika (134299), Takafumi Abe (2185522), Minoru Isomura (299507), Kenju Akai (6021194), Kenta Okuyama (1670404)   +5 more
core   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Resistant Hypertension: Integration of Novel Agents and Interventional Approaches in Clinical Practice

Reviews in Cardiovascular Medicine
Resistant hypertension (RH) is a high-risk phenotype characterized by blood pressure readings ≥130/80 mmHg despite maximally tolerated therapy with three antihypertensive agents, including a diuretic, or controlled blood pressure requiring four or more ...
Jose Arriola-Montenegro, Andres Chaponan-Lavalle, Natalia Nombera-Aznaran, Mohammed Abdalla, Benjamin Bizer, Arjunmohan Mohan, Irma Andrea Muñoz Verdugo, Pooya Zardoost, Karina Ordaya-Gonzales, Alan Villarreal Rizzo, Wagner Rios-Garcia, Laverne Kar Yin Yip, Maria L. Gonzalez Suarez   +12 more
doaj   +1 more source