Results 41 to 50 of about 198 (133)
High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench
Journal of Bone and Mineral Research, Volume 38, Issue 2, Page 229-247, February 2023., 2023 ABSTRACT Monogenic high bone mass (HBM) disorders are characterized by an increased amount of bone in general, or at specific sites in the skeleton. Here, we describe 59 HBM disorders with 50 known disease‐causing genes from the literature, and we provide an overview of the signaling pathways and mechanisms involved in the pathogenesis of these ...
Dylan J.M. Bergen +19 more
wiley +1 more source
CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis
Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022 CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma +9 more
wiley +1 more source
Mouse models of patent ductus arteriosus (PDA) and their relevance for human PDA
Developmental Dynamics, Volume 251, Issue 3, Page 424-443, March 2022., 2022 Key Findings Mouse models of patent ductus arteriosus (PDA) are informative for human PDA. Human single‐gene disorders with a PDA phenotype reveal interacting networks that contribute to regulation of DA patency and closure. Cross‐species correlations identify pathways of interest for development of PDA therapeutics. Abstract The ductus arteriosus (DA)
Michael T. Yarboro +4 more
wiley +1 more source
, 2023 HemaSphere, Volume 7, Issue S3, August 2023.
Ganesh Kumar Viswanathan +6 more
wiley +1 more source
JGH Open, Volume 6, Issue 2, Page 100-111, February 2022., 2022 Immune‐mediated inflammatory diseases (IMIDs) of the gastrointestinal tract including inflammatory bowel disease (IBD) are a diverse group of complex inflammatory diseases that share similar pathophysiology. IMIDs other than IBD can have similar clinical features causing diagnostic and therapeutic challenges.
Sudheer K Vuyyuru +3 more
wiley +1 more source
A Rare Cause of Refractory Anaemia hidden between Folds
, 2023 British Journal of Haematology, Volume 202, Issue 4, Page 712-712, August 2023.
Syna Hamani +3 more
wiley +1 more source
Doege-Potter Syndrome with a Benign Solitary Fibrous Tumor: A Case Report and Literature Review
Case Reports in Oncology, 2021 Doege-Potter syndrome is a rare paraneoplastic syndrome that is often diagnosed incidentally during the workup of hypoglycemia of unclear etiology. It is characterized by a non-islet cell tumor hypoglycemia secondary to excessive production of partially ...
Turab Mohammed +5 more
doaj +1 more source
An Expert Perspective on Phosphate Dysregulation With a Focus on Chronic Hypophosphatemia
Journal of Bone and Mineral Research, Volume 37, Issue 1, Page 12-20, January 2022., 2022 ABSTRACT Because of their rarity, diseases characterized by chronic hypophosphatemia can be underrecognized and suboptimally managed, resulting in poor clinical outcomes. Moreover, serum phosphate may not be measured routinely in primary care practice.
Fahad Aljuraibah +11 more
wiley +1 more source
Mediators of Inflammation, Volume 2022, Issue 1, 2022., 2022 Osteoarthritis (OA) is a severe inflammation‐related disease which leads to cartilage destruction. The retinoic acid receptor gamma (RARγ) has been indicated to be involved in many inflammation processes. However, the role and mechanism of RARγ in cartilage destruction caused by inflammation in OA are still unknown.
Yue-Wei Yu +9 more
wiley +1 more source
Journal of Medical Case Reports, 2018 Background Primary hypertrophic osteoarthropathy also known as pachydermoperiostosis is a rare genetic disorder that has often been confused with acromegaly because of similar clinical features.
Yacoba Atiase +6 more
doaj +1 more source