Results 51 to 60 of about 1,313 (164)

Insights Into Late‐Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets

Geriatrics &Gerontology International, Volume 26, Issue 2, February 2026.
The main features of late‐onset rheumatoid arthritis (LORA), manifesting after age 65, are acute onset, higher disease activity, systemic involvement, and less presence of autoantibodies. Management requires individualized strategies, balancing aggressive treat‐to‐target therapy in robust patients with frailty‐focused approaches to prevent geriatric ...
Fausto Salaffi, Marina Carotti, Sonia Farah, Francesca Bandinelli, Luca Ceccarelli, Andrea Di Matteo, Marco Di Carlo   +6 more
wiley   +1 more source

Baqueteamento digital como manifestação inicial de neoplasia pulmonar Digital clubbing as the initial diagnosis of bronchogenic cancer

Anais Brasileiros de Dermatologia, 2004
Os autores descrevem caso de baqueteamento digital, o qual possibilitou diagnóstico de carcinoma broncogênico em paciente assintomático. Baseados em levantamento bibliográfico, discutem sua fisiopatologia, associações com alterações sistêmicas e métodos ...
Alex Gonçalves Macedo, Valeria Cristiane Fusari, José Roberto Paes de Almeida, Sandra Lopes Mattos e Dinato, Ney Romiti   +4 more
doaj   +1 more source

Beyond Cystic Fibrosis: Recognising Shwachman‐Diamond Syndrome in the Respiratory Clinic

Respirology Case Reports, Volume 13, Issue 12, December 2025.
Our case shows how SDS can mimic CF (borderline sweat electrolytes, recurrent lower respiratory infections, pancreatic insufficiency) but diverge in trajectory and management. Over 42 years, our patient demonstrated: (1) recurrent infections, (2) persistent pancreatic insufficiency and (3) intermittent neutropenia.
Freda Yang, Ladina Weitnauer, Imogen Felton, Nicholas J. Simmonds   +3 more
wiley   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

Primary Hypertrophic Osteoarthropathy (Pachydermoperiostosis): Two Brothers Misdiagnosed As Inflammatory Arthritis

Trends in Urology &Men's Health, Volume 16, Issue 4, August 2025.
ABSTRACT Primary hypertrophic osteoarthropathy (Pachydermoperiostosis) is a rare, inherited genetic disorder of the skeleton and the skin, characterised by clubbing of the fingers, thickening of the skin especially of the face and forehead (pachydermia) and periostosis. Patients often present with pain and swelling of the knees and ankles.
Ahmed AbdulBari, Farooq Fouad, Sarah Mushtaq, Ali Jawad   +3 more
wiley   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

Primary Hypertrophic Osteoarthropathy: A Case Series

Journal of Marine Medical Society
Primary hypertrophic osteoarthropathy (PHOA) is a rare genetic disorder defined by digital clubbing, periostosis of long bones, and musculoskeletal pain.
Ramakant Singh, Kunal Kishore, J. Sankar, Avneet Kumar Gupta, Abhishek Kumar, Dev Prakash Sharma, Puran Padwal   +6 more
doaj   +1 more source

Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature

BMC Musculoskeletal Disorders, 2018
Background Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities.
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti   +4 more
doaj   +1 more source

Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single‐Cell Sequencing Analysis

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Background The nucleus pulposus (NP) plays a central role in the pathogenesis of intervertebral disc degeneration (IVDD); however, its internal cellular heterogeneity and molecular mechanisms have not yet been elucidated. Methods ScRNA‐seq was used to evaluate the structure of the NP at different degenerative stages in the same individual with IVDD ...
Chen Liu, Kun Jiao, Xiaoyu Li, Zixiang Deng, Shanhe Wang, Yajun Cheng, Ming Li, Xiaoyi Zhou, Xianzhao Wei, Jingru Tian   +9 more
wiley   +1 more source

Radiofrequency ablation: mechanisms and clinical applications

MedComm, Volume 5, Issue 10, October 2024.
Radiofrequency ablation (RFA) is a type of thermal ablation that induces coagulation necrosis of tumors by raising temperatures above 60°C. However, compared with complete RFA, because the ablation area cannot completely cover the entire tumor, insufficient RFA (iRFA) can lead to rapid local tumor progression, metastasis, and even further malignant ...
Jianhua Wu, Zhiyuan Zhou, Yuanwen Huang, Xinyue Deng, Siting Zheng, Shangwen He, Genjie Huang, Binghui Hu, Min Shi, Wangjun Liao, Na Huang   +10 more
wiley   +1 more source