Results 1 to 10 of about 12,621 (181)

LNVA for treating secondary lymphedema: A systematic review [PDF]

JPRAS Open
Secondary lymphedema is a frequent long-term complication following cancer treatment. Although several surgical options exist, lymph node-to-vein anastomosis (LNVA) has recently gained renewed attention as a potential treatment for secondary lymphedema ...
Caroline Lilja, Wahida Chakari, Jens Ahm Sørensen, Jørn Bo Thomsen   +3 more
doaj   +2 more sources

Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development [PDF]

Clinical and Translational Medicine
Background Secondary lymphedema is a common complication of cancer treatment and epidermal changes are recognised as histological hallmarks of secondary lymphedema; however, the role of keratinocytes in the pathophysiology of this disease remains unclear.
Hyeung Ju Park, Sarit Pal, Xizhao Chen, Jinyeon Shin, Gabriela D. García Nores, Jung Eun Baik, Annica Stull‐Lane, Abraham J. Book, Cristina C. Clement, Elizabeth M. Encarnacion, Mark G. Klang, Elyn Riedel, Tafadzwa L. Chaunzwa, Geoffrey E. Hespe, Laura Santambrogio, Michelle Coriddi, Joseph H. Dayan, Babak J. Mehrara, Raghu P. Kataru   +18 more
doaj   +2 more sources

Establishment of a long-term secondary lymphedema animal model in the rodent hindlimb [PDF]

Frontiers in Surgery
IntroductionSecondary lymphedema is a chronic swelling of the extremities caused by physical disruption of the lymphatic system, leading to impaired lymph drainage.
Sung-Hwan Yoon, Hyun Suk Peter Suh, Jin-Hui Yoon, Hayeong Cho, Yujin Myung, Jae Yong Jeon   +5 more
doaj   +2 more sources

Hyperspectral imaging as an objective diagnostic tool for secondary lymphedema in breast cancer patients [PDF]

Communications Medicine
Background Secondary lymphedema is a common complication after breast cancer treatment. Traditional diagnostic techniques often lack objectivity, are prone to operator bias, and show limited reproducibility.
Martin Weiss, Ovidiu Jurjuț, Astrid Ehrhardt, Anaclara Herholz, Anna Seller, Adrien Daigeler, Markus Hahn, Mario Marx, Lukas Schimunek, Wiebke Eisler   +9 more
doaj   +2 more sources

Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling [PDF]

Journal of Orthopaedic Translation
Background: Secondary lymphedema, a progressive disorder characterized by pathological fibroadipose tissue accumulation, is a common problem after cancer treatment and orthopedic surgery.
Ziyu Chen, Zhi Yao, Mengfan Wu, Yuluan Wu, Jianlin Zhang, Zhuangyao Liao, Junyu Qian, Jiewen Wei, Lili Song, Longbiao Yu, Jingjing Wen, Zhegang Zhou, Yihao Wei, Yuefeng Yao, Zetao Ma, Pei Liu, Shailesh Agarwal, Ye Li, Lixiang Xue, Deli Wang   +19 more
doaj   +2 more sources

M2 macrophage−derived exosomes improves secondary lymphedema through cellular mitochondrial homeostasis regulation via the Keap1-Nrf2/mPTP axis [PDF]

Frontiers in Immunology
BackgroundSecondary lymphedema leads to progressive tissue remodeling and immune dysregulation. Dysregulation of macrophage polarization critically influences pathological progression.
Jinli Ma, Jinli Ma, Jinli Ma, Luya Pu, Luya Pu, Luya Pu, Yundong Zhang, Yundong Zhang, Yundong Zhang, Baiao Wu, Baiao Wu, Baiao Wu, Rui Fei, Rui Fei, Rui Fei, Dongmei Han, Dongmei Han, Dongmei Han, Miao Hao, Miao Hao, Miao Hao, Jianshi Du, Jianshi Du, Jianshi Du   +23 more
doaj   +2 more sources

Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice [PDF]

iScience
Summary: Secondary lymphedema is a debilitating chronic tissue swelling in a limb caused by inadequate interstitial fluid drainage due to dysfunctional lymphatic vessels.
Yinan Yuan, Sidney M. Levy, Yong Qiang Yeo, Ramin Shayan, Tara Karnezis, Steven A. Stacker, Marc G. Achen   +6 more
doaj   +2 more sources

TGF-β–mediated epithelial-mesenchymal transition of keratinocytes promotes fibrosis in secondary lymphedema [PDF]

JCI Insight
Secondary lymphedema is characterized by fibrosis and impaired lymphatic function. Although TGF-β is a key regulator of fibrosis in this disease, the cellular mechanisms regulating this process remain unknown.
Hyeung Ju Park, Jinyeon Shin, Ananta Sarker, Mark G. Klang, Elyn Riedel, Michelle Coriddi, Joseph H. Dayan, Sarit Pal, Babak J. Mehrara, Raghu P. Kataru   +9 more
doaj   +2 more sources

Development of a rat model of lymphedema and the implantation of a collagen-based medical device for therapeutic intervention

Frontiers in Cardiovascular Medicine, 2023
Secondary lymphedema is a common condition among cancer survivors, and treatment strategies to prevent or treat lymphedema are in high demand. The development of novel strategies to diagnose or treat lymphedema would benefit from a robust experimental ...
Dung Nguyen, Dimitrios Dionyssiou, Tatiana S. Zaitseva, Anna T. Zhou, Gloria Sue, Peter Deptula, Maxim A. Moroz, Peter Tabada, Stanley G. Rockson, Michael V. Paukshto, Ming-Huei Cheng, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang   +14 more
doaj   +1 more source

Current Concepts in the Management of Primary Lymphedema

Medicina, 2023
Primary lymphedema is a heterogeneous group of conditions encompassing all lymphatic anomalies that result in lymphatic swelling. Primary lymphedema can be difficult to diagnose, and diagnosis is often delayed. As opposed to secondary lymphedema, primary
Jenna-Lynn B. Senger, Rohini L. Kadle, Roman J. Skoracki   +2 more
doaj   +1 more source