Results 181 to 190 of about 1,364,633 (308)

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Comparative genomics of Brucella species reveals key determinants of secondary metabolism, antimicrobial resistance, and virulence. [PDF]

Sci Rep
Liu X, Zhang R, Sun M, Qiao J, Liang M.
europepmc   +1 more source

Pain and Patient‐Reported Physical Function Did Not Differ Among Body Composition Profiles in Patients With Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective To explore whether higher body fat and lower lean mass are associated with greater pain and worse patient‐reported physical function in individuals with hip osteoarthritis (OA). A secondary aim was to examine whether pain and patient‐reported physical function differ according to four body composition profiles: high body fat, low lean mass ...
Alexandra Ryan, Boliang Wang, Fiona Dobson, Ben Kirk, Travis Haber, Kim L. Bennell, Shirley P. Yu, Kim Allison, Ricardo J. S. Costa, Gabrielle Knox, Michelle Hall   +10 more
wiley   +1 more source

Microalgal extracts optimize lettuce quality through extraction-method-dependent modulation of primary and secondary metabolism. [PDF]

BMC Biotechnol
Chanda MJ, Soidihane A, Mounaimi S, Alaoui MH, Lamaden H, Lyamlouli K, Arroussi HE.   +6 more
europepmc   +1 more source

Obesity subtypes and longitudinal trajectories of function over 7‐years of follow‐up: data from the Multicenter Osteoarthritis Study

Arthritis Care &Research, Accepted Article.
Background Obesity, defined by BMI ≥30kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA.
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi   +6 more
wiley   +1 more source

Metabolomics Reveals Resistance-Related Secondary Metabolism in Sweet Cherry Infected by <i>Alternaria alternata</i>. [PDF]

Biomolecules
Yuan H, Gao H, Duan S, Zhou X, Yang X, Sun B, Ren H, Zheng Z, Guo Q.   +8 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Role of the osaA Transcription Factor Gene in Development, Secondary Metabolism and Virulence in the Mycotoxigenic Fungus Aspergillus flavus. [PDF]

Toxins (Basel)
Hossain FE, Dabholkar A, Lohmar JM, Lebar MD, Mack BM, Calvo AM.   +5 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source