Results 141 to 150 of about 7,098,586 (333)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Secondary Metabolites from the Roots of

Natural Product Communications, 2011
Two novel secondary metabolites, compounds ( 1–2 ) were isolated from the roots of Paronychia chionaea. On the basis of spectroscopic data including 1D and 2D NMR experiments (COSY, TOCSY, HSQC, and HMBC), and mass spectroscopy, their structures were ...
Sibel Avunduk, Özgen Alankuş-Çalişkan, Tomofumi Miyamoto, Chiaki Tanaka, Marie-Aleth Lacaille-Dubois   +4 more
doaj   +1 more source

Investigating the diversity of secondary metabolites from filamentous fungi [PDF]

, 2017
Natural products continue to be a fertile source of leads for drug discovery, as a large extent of the world’s biodiversity has been untapped for their chemical diversity and biological activity.
NC DOCKS at The University of North Carolina at Greensboro, Paguigan, Noemi D.   +1 more
core  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Elicitor-mediated enhancement of secondary metabolites in plant species: a review

Frontiers in Plant Science
Plant metabolites play a vital role in a plant’s defense system. Plant metabolites are extensively studied for their therapeutic values. Plant therapeutic values are attributed based on the magnitude of metabolites.
Abdul Razzaq, Abdul Razzaq, Abdul Razzaq, Abdul Razzaq, Muhammad Mubashar Zafar, Muhammad Mubashar Zafar, Muhammad Mubashar Zafar, Aima Ali, Lubna Ihsan, Fariha Qadir, Fariha Qadir, M. Nasir Khan, Yingying Zhang, Yingying Zhang, Linmao Gao, Linmao Gao, Hanqing Cong, Hanqing Cong, Hanqing Cong, Rashid Iqbal, Rashid Iqbal, Xuefei Jiang, Fei Qiao, Fei Qiao, Fei Qiao, Fei Qiao, Fei Qiao   +26 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Isolation and Characterisation of Bacterial Metabolites as Potential Wood Preservatives [PDF]

, 2012
The durability of wood has traditionally relied on the use of heavy metals and toxic compounds to deter wood degrading fungi. Conventional wood preservatives such as Chromated Copper Arsenate (CCA) have been widely used to control wood degrade for many ...
O'Callahan, Diahanna Rachelle
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Optimization and characterization of bioactive secondary metabolites from Streptomyces sp CMSTAAHL-4 isolated from mangrove sediment

BMC Microbiology
Background Ten morphologically different actinomycetes were isolated from mangrove sediments of Manakudy, Kanyakumari District, India. The potent strain was selected based on their primary screening against Gram positive Staphylococcus aureus ...
Selvaraj Jeraldin Nisha, Ganapathi Uma, Ramamoorthy Sathishkumar, Vincent Samuel Gnana Prakash, Rimal Isaac, Thavasimuthu Citarasu   +5 more
doaj   +1 more source