Results 131 to 140 of about 7,098,586 (333)

Correlation analysis of secondary metabolites and disease resistance activity of different varieties of Congou black tea based on LC-MS/MS and TCMSP

Food Chemistry: X
To investigate the correlation between the difference of secondary metabolites and the disease-resistance activity of different varieties of Congou black tea.
Zhongying Liu, Qiansong Ran, Jinlong Luo, Qiang Shen, Tuo Zhang, Shimao Fang, Ke Pan, Lin Long   +7 more
doaj   +1 more source

Secondary metabolite research in Malaysia: current status and future prospects

, 2018
Herbal medicine is gaining acceptance worldwide for their effective pharmacological effects and relative safety. Plants have metabolic pathways that lead to the production and accumulation of secondary metabolites such as alkaloids, glycosides, and ...
Mohd. Salleh, Hamzah, Zainurin, Nur Aimi Aliah, Ahmad Fuad, Fazia Adyani, Noor Illi Mohamad Puad, Fazia Adyani Ahmad Fuad, Nur Aimi Aliah Zainurin, Hashim, Yumi Zuhanis Has-Yun, Mohamad Puad, Noor Illi, Yumi Zuhanis Has-Yun Hashim, Eissa, Manar, Hamzah Mohd. Salleh, Manar Eissa   +11 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine and Terrestrial Organisms. [PDF]

, 2011
Natural products have historically been a rich source of “lead compounds” in drug discovery. The investigation of terrestrial plants and marine organisms aimed at searching new biologically active compounds is a central issue of this kind of studies ...
Chianese, Giuseppina
core   +1 more source

Antioxidant Effects of Secondary Metabolites from

Natural Product Communications, 2010
An investigation was made of the effects on endogenous antioxidant enzyme activities and H 2 O 2 -induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n -BuOH, and H 2 O sub-extracts obtained from aerial
Didem Şöhretoğrlu, Suna Atasayar Sabuncuoğrlu, M. Koray Sakar, Hilal Özgüneş, Olov Sterner   +4 more
doaj   +1 more source

Biosynthesis of secondary metabolites in sugarcane

Genetics and Molecular Biology, 2001
A set of genes related to secondary metabolism was extracted from the sugarcane expressed sequence tag (SUCEST) database and was used to investigate both the gene expression pattern of key enzymes regulating the main biosynthetic secondary metabolism ...
S.C. França, P.G. Roberto, M.A. Marins, R.D. Puga, A. Rodrigues, J.O. Pereira   +5 more
doaj   +1 more source

Pharmacognosical Study on Secondary Metabolites

YAKUGAKU ZASSHI, 2000
Clonal micropropagation on various medicinal plants was set up resulting in the regenerated plants which possessed a homogeneous quality. The ratio of hapten to bovine serum albumin (BSA) in an antigen conjugate was determined by matrix-assisted laser desorption/ionization of mass spectrometry.
openaire   +3 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Secondary metabolites from marine microorganisms

Anais da Academia Brasileira de Ciências, 2002
After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the
KELECOM ALPHONSE
doaj  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source