Results 71 to 80 of about 4,135,145 (344)

Secondary Metabolites from Rubiaceae Species

Molecules, 2015
This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae,
Daiane Martins, Cecilia Veronica Nunez
doaj   +1 more source

Insecticidal Activity of Plant Secondary Metabolites

Plants, 2022
Plant-insect interactions are one of the most fascinating fields of research attracting biologists, entomologists, botanists, as well as a wide range of multidisciplinary researchers [...]
Giovanni Benelli, Filippo Maggi
doaj   +1 more source

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Molecules, 2021
Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging.
Mayadah B. Shehadeh, G. Suaifan, Alaa M. Abu-Odeh   +2 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Spring Abundance, Migration Patterns and Damaging Period of Aleyrodes proletella in the Czech Republic

Agronomy
The cabbage whitefly has become an important pest on brassica vegetables in Central Europe. It does not destroy the affected plants, but the product becomes unmarketable, causing considerable economic losses.
Kamil Holý, Kateřina Kovaříková
doaj   +1 more source

Secondary Metabolites from the Fungus

Natural Product Communications, 2013
A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans , together with koninginin E (2), koninginin A (3), trichodermatide B (4), citrantifidiol (5), (4 S ,5 R )-4-hydroxy-5-methylfuran-2-one (6), the glycerol
Amer H. Tarawneh, Francisco León, Mohamed M. Radwan, Luiz H. Rosa, Stephen J. Cutler   +4 more
doaj   +1 more source

Stress and defense responses in plant secondary metabolites production

Biological Research, 2019
In the growth condition(s) of plants, numerous secondary metabolites (SMs) are produced by them to serve variety of cellular functions essential for physiological processes, and recent increasing evidences have implicated stress and defense response ...
T. Isah
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Trichoderma: A Treasure House of Structurally Diverse Secondary Metabolites With Medicinal Importance

Frontiers in Microbiology, 2021
Fungi play an irreplaceable role in drug discovery in the course of human history, as they possess unique abilities to synthesize diverse specialized metabolites with significant medicinal potential.
Jian-Long Zhang, Wenli Tang, Qingrong Huang, Youzhi Li, Maolian Wei, Linlin Jiang, Chong Liu, Xin Yu, Hongwei Zhu, Guozhong Chen, Xingxiao Zhang   +10 more
semanticscholar   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source