Results 81 to 90 of about 8,349,404 (268)

Effects of Vitamin B12 and Folic Acid Supplementation on Negative Symptoms as the Primary Outcome and Positive and Cognitive Symptoms as Secondary Outcomes in Schizophrenia: A Randomized Controlled Trial

open access: yesIranian Journal of Psychiatry
Objective: Persistent negative symptoms in chronic schizophrenia often show limited responsiveness to antipsychotic therapy. The present study evaluated whether supplementation with vitamin B12 and folic acid improves negative symptoms as the primary endpoint, while also examining effects on positive symptoms and global cognitive functioning as ...
Mahnaz Shah Ali   +3 more
openaire   +1 more source

Current developments and challenges in the assessment of negative symptoms.

open access: yes, 2016
International audienceReliable and valid assessment of negative symptoms is crucial to further develop etiological models and improve treatments.
Lyne, J, Dollfus, S, Lincoln, Tm
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin   +11 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Addressing negative symptoms of schizophrenia in a Psychosis Day Hospital: a case report

open access: yesEuropean Psychiatry
Introduction Negative symptoms are present in more than two thirds of schizophrenic patients throughout the evolution of the disorder. These include symptoms related to reduced motivation or pleasure, such as avolition, anhedonia and asociality, and ...
F. Mayor Sanabria   +7 more
doaj   +1 more source

Yogic breathing instruction in patients with treatment-resistant generalized anxiety disorder: Pilot study

open access: yesInternational Journal of Yoga, 2019
Aim: This study aims to evaluate the feasibility and effects of instruction in yogic breathing techniques (Pranayama) in patients with treatment-resistant generalized anxiety disorder (GAD) in UK secondary mental health services settings.
Nupur Tiwari   +3 more
doaj   +1 more source

Roles of attachment, reflective function and emotion regulation in the development of negative symptoms

open access: yes, 2019
In the context of developmental psychopathology and the psychological and social risk factors associated with psychosis and ‘schizophrenia’, this thesis proposes that early attachment interactions underlie the development of reflective function and ...
Thomson, Alice
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Neurocognitive Deficits, Negative Symptoms, and Insight in Schizophrenia

open access: yes, 2011
The symptom domains of primary negative symptoms, insight and cognitive deficits in schizophrenia appear to overlap on a number of aspects. These domains are: (1) relatively independent of the psychotic, affective and secondary negative symptoms domains;
Harvey, Philip   +2 more
core   +1 more source

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