Results 211 to 220 of about 4,266 (303)

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

Cancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu, Gang Yu, Yuan Liu, Yu Zhou, Wei Liu, Lin Wang, Lide Liu, Yan Liu, Tiejun Pan, Zhenyu Liu, Lei Gao   +10 more
wiley   +1 more source

From peers to partners: The peer-context origins of adolescent heterosexual romance. [PDF]

J Res Adolesc
McMillan C, Kreager DA, Veenstra R.
europepmc   +1 more source

Understanding the Link Between Social Support Networks, Self‐Efficacy and Future Orientation During Emerging Adulthood: A Comparison of At‐Risk and Non‐at‐Risk Emerging Adults

Child &Family Social Work, EarlyView.
ABSTRACT At‐risk emerging adults may be less inclined to invest in future goals, yet the mechanisms underlying their future orientation (FO) remain unclear. Therefore, this study examined how social support network attributes contribute to FO in at‐risk and non‐at‐risk emerging adults and the mediating role of self‐efficacy.
Eran P. Melkman, Yafit Sulimani‐Aidan
wiley   +1 more source

Bullying in Students with Attention Deficit/Hyperactivity Disorder (ADHD): Analyzing Students' Social Status and Student-Teacher Relationship Quality. [PDF]

Int J Environ Res Public Health
Mastrokoukou S, Berchiatti M, Badenes-Ribera L, Galiana L, Longobardi C.   +4 more
europepmc   +1 more source

Multiagency Collaborations to Support Well‐Being Amongst Care‐Experienced Children and Young People in School and During Transition to Further Education College: Stakeholder Perspectives on Facilitators, Challenges and Innovations

Child &Family Social Work, EarlyView.
ABSTRACT Multiagency collaboration to address care‐experienced children and young people's mental well‐being has been advocated as a way of attending to complex needs while avoiding fragmented support. Key sectors with a statutory role include education, mental health and social care, and there is increasing interest at a UK and global scale about ...
Sarah MacDonald, Gillian Hewitt, Siôn Jones, Alyson Rees, Rachel Brown, Rebecca Anthony, Rhiannon Evans   +6 more
wiley   +1 more source

Implications of the FDA's new plausible mechanism framework for the development of a personalized in vivo prime editing platform. [PDF]

Am J Hum Genet
Feierman ER, Whittaker MN, Quigley A, Brooks DL, McVeigh P, Nan AX, Hsu A, Said H, Soliman OY, Giovenco R, Davidson BL, Alameh MG, Liu DR, Wang X, Musunuru K, Ahrens-Nicklas RC.   +15 more
europepmc   +1 more source

Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease‐Like Colitis in Mice

Cell Proliferation, EarlyView.
This study elucidates the pivotal regulatory role and mechanism of MLL1 in inflammatory bowel disease. Experimental data demonstrated elevated MLL1 expression levels in TNBS‐induced murine colitis models, with pharmacological inhibition of MLL1 significantly promoting recovery from CD‐like colitis by accelerating intestinal barrier restoration ...
Xue Song, Jing Li, Yue Chen, Bohan Li, Yi Yang, Xiaofan Guan, Xiaofeng Zhang, Lu Tao, Zhijun Geng, Lugen Zuo, Yueyue Wang, Lian Wang, Jianguo Hu   +12 more
wiley   +1 more source

Friendship fosters well-being, exclusion may hurt girls' mathematics: a two-wave cross-lagged panel model of peer relations, affect, and achievement. [PDF]

Eur J Psychol Educ
Lintner T.
europepmc   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Artificial Intelligence-Driven SELEX Design of Aptamer Panels for Urinary Multi-Biomarker Detection in Prostate Cancer: A Systematic and Bibliometric Review. [PDF]

Biomedicines
Slalmi A, Rabbah N, Battas I, Debbarh I, Medromi H, Abourriche A.   +5 more
europepmc   +1 more source