Results 71 to 80 of about 4,266 (303)

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

The creative potential of the enchanter lexeme in literary texts оf the XX – early XXI centuries [PDF]

Актуальные проблемы филологии и педагогической лингвистики
The paper aims at establishing the specifics of the image of the enchanter in literary texts оf the XX-early XXI сenturies. Theoretical provisions related to the definition of linguistic characteristics of literary discourse are established, analyzed and
Natalya A. Segal , Polina S. Nalbandova, Galina Yu. Bogdanovich   +2 more
doaj   +1 more source

SECONDARY NOMINATION IN THE ENGLISH TERMINOLOGICAL SYSTEM FOR ANIMAL DISEASES

Mìžnarodnij fìlologìčnij časopis, 2023
This paper explored the problem of forming a secondary nomination in the English veterinary terminology on the example of terms for animal diseases. The aim of this study is to reveal the secondary nomination as one of the ways to replenish the terminology denoting animal diseases.
openaire   +1 more source

Secondary analysis of winners.

, 2022
Forest plot showing multiple sensitivity analyses of absolute increase in life-expectancy for winners in different subgroups. Referent group in all analyses is control performers with no win and no nomination. Circles denote estimate and horizontal lines
Sheldon M. Singh (12413147), Donald A. Redelmeier (11262854)   +1 more
core   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

THE ROLE OF PERCEPTIVE CHARACTERISTICS IN IDENTIFYING INTERPRETATION (basing on the material of lexical categories, objectifying the sphere “animal world” in German language)

Неофилология, 2016
The role of perceptual characteristics in the process of interpretive meanings of lexical units formation as the result of secondary nomination that is based on the interpretation of certain properties of the source concept represented by lexical units ...
Mariya Andreevna Zakharova
doaj  

Secondary nomination as a method of formation ofnew terminology units in banking and exchange terminology.

, 2011
У статті досліджується вторинна номінація як спосіб утворення нових термінологічних одиниць у банківській і біржовій термінології, також аналізується структура вторинно номінованих термінів і робиться висновок про спадковість інформації у вторинній ...
Rumiantseva, Olena A., Румянцева, Елена Анатольевна, Румянцева, Олена Анатоліївна   +2 more
core  

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Innovative artifacts of the unofficial anthroponymicon of Ukrainian politics in the contemporary metamodern discourse

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ.
The article is devoted to the study of current trends in unofficial naming, especially neogenic derivative processes. The author aims to explore innovative artifacts of the unofficial anthroponymicon of Ukrainian politics from the perspective of ...
Kateryna Diukar
doaj   +1 more source