Results 41 to 50 of about 790,254 (306)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Secondary Prevention

Abstract Secondary prevention tackles the difficult challenge of addressing the sequelae of IPV, during its “early stages,” both providing interventions so that IPV doesn’t happen again and before more acute or critical tertiary services are needed.
Jocelyn Anderson, Elizabeth A. Walker, Nancy Glass   +2 more
  +4 more sources

Stroke secondary prevention, a non-surgical and non-pharmacological consensus definition: results of a Delphi study

BMC Research Notes, 2019
Objective Evidence supporting lifestyle modification in vascular risk reduction is limited, drawn largely from primary prevention studies. To advance the evidence base for non-pharmacological and non-surgical stroke secondary prevention (SSP), empirical ...
Maggie Lawrence, Eric Asaba, Elaine Duncan, Marie Elf, Gunilla Eriksson, James Faulkner, Susanne Guidetti, Birgitta Johansson, Christina Kruuse, Danielle Lambrick, Caitlin Longman, Lena von Koch, Xu Wang, Olive Lennon   +13 more
doaj   +1 more source

Secondary Prevention and Extreme Cardiovascular Risk Evaluation (SEVERE-1), Focus on Prevalence and Associated Risk Factors: The Study Protocol [PDF]

, 2023
Alessandro Maloberti, Rita Cristina Myriam Intravaia, Costantino Mancusi, Arturo Cesaro, Enrica Golia, Ilaria Fucile, Silvio Coletta, Piera Angelica Merlini, Benedetta De Chiara, Davide Paolo Bernasconi, Michela Algeri, P Ossola, C Ciampi, A. Riccio, Chiara Tognola, Maddalena Ardissino, Elvira Inglese, Francesco Scaglione, Paolo Calabrò, Nicola De Luca, Cristina Giannattasio   +20 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The impact of demographic factors on the level of knowledge about primary and secondary prevention of cervical cancer among patients in Lublin voivodeship

Family Medicine & Primary Care Review, 2016
Background. Cervical cancer (CC) is among the most-commonly detected cancers affecting women worldwide. The primary means of preventing CC is the Human Papillomavirus (HPV) vaccine.
Anna Puzio, Krzysztof Kułak, Małgorzata Repa, Joanna Ruszczyk, Katarzyna Skórzyńska-Dziduszko   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Health prevention in the pediatric population - challenges and recommendations for the future

Journal of Education, Health and Sport
Introduction and purpose: The aim of this work is to deepen the topic of health prevention and to draw attention to the need for early intervention, a holistic approach to health and cooperation between family, school and health care.
Maria Antos-Łyko, Oliwia Regina Wasąg, Karina Aleksandra Koszuta, Przemysław Koszuta, Marcin Tkaczyk, Dawid Pająk, Piotr Czerniak, Julia Buszek, Paulina Laskowska, Adrian Pistelok   +9 more
doaj   +1 more source

Práticas de autocuidado em hanseníase: face, mãos e pés

Revista Gaúcha de Enfermagem, 2018
Resumo OBJETIVO Analisar as práticas de autocuidado em face, mãos e pés realizadas por pessoas atingidas pela hanseníase. METODOLOGIA Estudo qualitativo, realizado em unidades de referência para hanseníase em Pernambuco, entre maio de 2014 e abril de ...
Marize Conceição Ventin Lima, Fernanda Ribeiro Barbosa, Danielle Christine Moura dos Santos, Raphaela Delmondes do Nascimento, Stephanie Steremberg Pires D’Azevedo   +4 more
doaj   +1 more source