Results 61 to 70 of about 4,919,522 (294)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Secondary prevention of sudden cardiac death

Heart Rhythm O2, 2020
The prevention and treatment of sudden cardiac death (SCD) remains a significant public health challenge. For patients with a history of sudden death attributable to ventricular arrhythmia, implantable cardioverter-defibrillator (ICD) therapy is a ...
Neal A. Chatterjee, MD, MSc, Thomas D. Rea, MD, MPH   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Primary and Secondary Prevention of Colorectal Cancer

, 2014
Introduction Cancer is a worldwide problem as it will affect one in three men and one in four women during their lifetime. Colorectal cancer (CRC) is the third most frequent cancer in men, after lung and prostate cancer, and is the second most frequent ...
José Antonio Rodríguez-Montes, Pedro J. Tárraga López, Juan Solera Albero   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

MĂSURI DE PREVENIRE CARE URMĂRESC REDUCEREA CERERII DE DROGURI ŞI A CONSUMULUI ILICIT DE DROGURI

Studia Universitatis Moldaviae: Stiinte Sociale, 2017
Problematica drogurilor este şi va fi în permanenţă una dintre temele dominante ale vieţii sociopolitice nu doar din Republica Moldova, ci şi din întreaga lume, în dificila încercare de a găsi răspunsuri la multiplele şi complexele probleme legate de ...
Angela MIRON
doaj  

Health prevention in the pediatric population - challenges and recommendations for the future

Journal of Education, Health and Sport
Introduction and purpose: The aim of this work is to deepen the topic of health prevention and to draw attention to the need for early intervention, a holistic approach to health and cooperation between family, school and health care.
Maria Antos-Łyko, Oliwia Regina Wasąg, Karina Aleksandra Koszuta, Przemysław Koszuta, Marcin Tkaczyk, Dawid Pająk, Piotr Czerniak, Julia Buszek, Paulina Laskowska, Adrian Pistelok   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Prevention 1st by state mandate – Health promotion as an overarching educational goal and teaching principle in primary school curricula: A comparison between Austria, Germany and Switzerland

Current Issues in Sport Science
Introduction & Purpose Health is a basic prerequisite in leading a fulfilled life; thus, it is one of the major topics of our time. In line with the United Nations Sustainable Development Goals (UN SDG’s), especially Goals #3 “Good Health and Well ...
Katharina C. Wirnitzer, Isabella Troppe, Derrick R. Tanous   +2 more
doaj   +1 more source

The impact of demographic factors on the level of knowledge about primary and secondary prevention of cervical cancer among patients in Lublin voivodeship

Family Medicine & Primary Care Review, 2016
Background. Cervical cancer (CC) is among the most-commonly detected cancers affecting women worldwide. The primary means of preventing CC is the Human Papillomavirus (HPV) vaccine.
Anna Puzio, Krzysztof Kułak, Małgorzata Repa, Joanna Ruszczyk, Katarzyna Skórzyńska-Dziduszko   +4 more
doaj   +1 more source