Results 61 to 70 of about 790,254 (306)

Application of the 2019 ESC/EAS dyslipidemia guidelines to a Mexican population: evaluating treatment targets for secondary prevention in clinical practice [PDF]

, 2021
Cesar Ivan Laguna, Rodrigo Reyes Pavón, H Reyes, D M Perales Rivera, Manuel Odin de Los Rios Ibarra   +4 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Genomic analysis of multidrug-resistant Salmonella enterica Serovar Montevideo isolates in China

BMC Genomics
Background As an important foodborne bacterium, non-typhoidal Salmonella (NTS) is estimated to cause approximately 215,000 deaths worldwide each year. Globally, S.
Zhenhua Liu, Qiang Wang, Wenqing Wang, Jin Ding, Panpan Lv, Yue Jiang, Xuzhi Wang, Yue Liu, Chengjie Zhang, Chi Zhang, Lingfei Luo, Yibin Zhou, Xuebin Xu, Mingliang Chen   +13 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

ACETYLSALICYLIC ACID IN PRIMARY AND SECONDARY PREVENTION OF STROKE

Атеротромбоз, 2017
Prevention of stroke remains one of the most pressing healthcare issues. Acetylsalicylic acid (ASA) is the only antithrombotic drug used for primary and secondary prevention of atherothrombotic stroke.
P. S. Laguta
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

SCREENING: THE CORNERSTONE FOR SECONDARY PREVENTION

Gomal Journal of Medical Sciences, 2018
Screening test sorts out from apparently healthy population those who probably have the disease or risk factor. Screening test is quick, less accurate, inexpensive and simple to be conducted by technicians, thereby saving doctors time who only interprets
Iftikhar Ahmad
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Impact of activity trackers on secondary prevention in patients with coronary artery disease: a systematic review and meta-analysis (Preprint)

, 2021
Toshiki Kaihara, Valent Intan-Goey, Martijn Scherrenberg, Maarten Falter, Ines Frederix, Paul Dendale   +5 more
openalex   +1 more source