Results 21 to 30 of about 19,445,077 (386)

UFold: fast and accurate RNA secondary structure prediction with deep learning

bioRxiv, 2020
For many RNA molecules, the secondary structure is essential for the correction function of the RNA. Predicting RNA secondary structure from nucleotide sequences is a long-standing problem in genomics, but the prediction performance has reached a plateau
Laiyi Fu, Yingxin Cao, Jie Wu, Qinke Peng, Q. Nie, Xiaohui S. Xie   +5 more
semanticscholar   +1 more source

Changes in protein structure at the interface accompanying complex formation

IUCrJ, 2015
Protein interactions are essential in all biological processes. The changes brought about in the structure when a free component forms a complex with another molecule need to be characterized for a proper understanding of molecular recognition as well as
Devlina Chakravarty, Joël Janin, Charles H. Robert, Pinak Chakrabarti   +3 more
doaj   +1 more source

Experimental Study of Improving the Durability of a Cup Cutter by Pre-Processing

Journal of Manufacturing and Materials Processing, 2023
This article presents the results of an experimental study on improving the durability of cup cutters through pre-processing. A review of existing methods of increasing the durability of metal-cutting tools is carried out.
Almat Sagitov, Karibek Sherov, Bakhtiyor Mardonov, Yerzhan Akhmetov, Zhanat Ramazanova, Saule Ainabekova, Gulerke Tattimbek, Gulim Tussupbekova, Azimbek Esirkepov   +8 more
doaj   +1 more source

Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

eLife, 2018
The structural interconversions that mediate the gene regulatory functions of RNA molecules may be different from classic models of allostery, but the relevant structural correlations have remained elusive in even intensively studied systems.
Siqi Tian, Wipapat Kladwang, Rhiju Das
doaj   +1 more source

Improving Membrane Activity and Cargo Delivery Efficacy of a Cell-Penetrating Peptide by Loading with Carboranes

Pharmaceutics, 2021
Cell-penetrating peptides (CPPs) have emerged as versatile tools to increase the intracellular accumulation of different kinds of cargoes. For an efficient cellular uptake and drug delivery, their organization into a distinct and stable secondary ...
Tamara Lützenburg, Nele Burdina, Matthias S. Scholz, Ines Neundorf   +3 more
doaj   +1 more source

RNA secondary structure prediction from multi-aligned sequences [PDF]

, 2013
It has been well accepted that the RNA secondary structures of most functional non-coding RNAs (ncRNAs) are closely related to their functions and are conserved during evolution.
A Balik, A Pauli, A Wilm, A Wilm, AC Penn, AR Gruber, AS Richter, B Knudsen, B Knudsen, C Witwer, CB Do, D Jager, D Sankoff, D Wei, DH Mathews, DH Mathews, E Bindewald, E Freyhult, E Rivas, EJ Meer, H Kiryu, H Yonemoto, IA Qureshi, IL Hofacker, IL Hofacker, IV Novikova, J Ruan, J Spirollari, JG Underwood, JM Watts, JR Proctor, JS McCaskill, JT Low, K Katoh, K Sato, K Sato, K Sato, KM Wong, LE Carvalho, M Andronescu, M Andronescu, M Esteller, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Kertesz, ME Nebel, MS Andronescu, P Ge, PP Gardner, PS Pang, R Luck, RD Dowell, RJ Klein, S Washietl, S Washietl, S Washietl, S Washietl, SE Seemann, SE Seemann, SH Bernhart, SM Sahraeian, SW Burge, T Puton, T Xia, Y Kato, Z Sukosd   +71 more
core   +1 more source

Three-Dimensional Printing Parameter Optimization for Salmon Gelatin Gels Using Artificial Neural Networks and Response Surface Methodology: Influence on Physicochemical and Digestibility Properties

Gels, 2023
This study aimed to optimize the 3D printing parameters of salmon gelatin gels (SGG) using artificial neural networks with the genetic algorithm (ANN-GA) and response surface methodology (RSM).
Nailín Carvajal-Mena, Gipsy Tabilo-Munizaga, Marleny D. A. Saldaña, Mario Pérez-Won, Carolina Herrera-Lavados, Roberto Lemus-Mondaca, Luis Moreno-Osorio   +6 more
doaj   +1 more source

Conformational and Structural Changes in Chickpea Proteins Caused by Simulated Salivary Alterations in the Elderly

Foods, 2023
The impact of salivary alterations on chickpea protein structure in the elderly has not been well documented. This study aimed to understand the role of simulated salivary alterations in the conformational properties and secondary structure of the ...
Ingrid Contardo, Fanny Guzmán, Javier Enrione   +2 more
doaj   +1 more source

BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra

Nucleic Acids Res., 2018
Circular dichroism (CD) spectroscopy is a widely used method to study the protein secondary structure. However, for decades, the general opinion was that the correct estimation of β-sheet content is challenging because of the large spectral and ...
András Micsonai, F. Wien, Éva Bulyáki, J. Kun, Éva Moussong, Young-Ho Lee, Y. Goto, M. Réfrégiers, J. Kardos   +8 more
semanticscholar   +1 more source

A Novel Motif in the 3′-UTR of PRRSV-2 Is Critical for Viral Multiplication and Contributes to Enhanced Replication Ability of Highly Pathogenic or L1 PRRSV

Viruses, 2022
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) with enhanced replication capability emerged in China and has become dominant epidemic strain since 2006.
Junyao Xiong, Xingyang Cui, Kuan Zhao, Qian Wang, Xinyi Huang, Dongyan Li, Fang Yu, Yongbo Yang, Di Liu, Zhijun Tian, Xuehui Cai, Tongqing An   +11 more
doaj   +1 more source