Results 101 to 110 of about 3,613,646 (331)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Method and apparatus for nondestructive testing [PDF]

, 1974
High voltage is applied to an arc gap adjacent to a test specimen to develop a succession of high frequency arc discharges. Those high frequency arc discharges generate pulses of ultrasonic energy within the test specimen without requiring the arc ...
Hoop, J. M.
core   +1 more source

EIGEN: Ecologically-Inspired GENetic Approach for Neural Network Structure Searching from Scratch

, 2019
Designing the structure of neural networks is considered one of the most challenging tasks in deep learning, especially when there is few prior knowledge about the task domain.
Foran, David J., Li, Zhe, Ren, Jian, Xu, Ning, Yang, Jianchao, Yang, Tianbao   +5 more
core   +1 more source

Larger fragments have more late‐successional species of woody plants than smaller fragments after 50 years of secondary succession

Journal of Ecology, 2018
Most fragmentation research focuses on the effects of carving up old‐growth forests, but less is known about influences of habitat fragmentation on secondary succession in patches of regenerating forests. Working with forest dynamics on islands in a vast
Jiajia Liu, D. Coomes, Guang Hu, Jinliang Liu, Jingjing Yu, Yangqing Luo, Mingjian Yu   +6 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Secondary succession on grasss slopes. II

Journal of the Japanese Institute of Landscape Architects, 1966
Nowadays the grass seeding methods having been spread out over most of roadside slopes, we should positively consider the problem of the restoration or the creation of the landscape by the vegetation, in the aspects of the road landscape planning.The landscape analysis of the micro-environment also becomes an indispensable process for the road ...
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Integration of vegetation inventory data and thematic mapper image for Amazonian successional and mature forest classification. [PDF]

, 2019
Successional and mature forest classification is often difficult in moist tropical regions. This paper explores vegetation stand structures of successional and mature forests and their spectral characteristics.
BATISTELLA, M., LU, D., MORAN, E. F.
core