Results 111 to 120 of about 3,613,646 (331)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Secondary succession of shrub-herb communities in the hilly area of Taihang Mountain. [PDF]
Front Plant Sci, 2023 Liu X, Zhou W, Li X, Zhang Y, Dong W.
europepmc +1 more source
Emerging Urban Forests: Opportunities for Promoting the Wild Side of the Urban Green Infrastructure [PDF]
, 2019 Many cities aim to increase urban forest cover to benefit residents through the provision of ecosystem services and to promote biodiversity. As a complement to traditional forest plantings, we address opportunities associated with “emerging urban forests”
Buchholz, Sascha +5 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Effects of processes at the population and community level on carbon dynamics of an ecosystem model [PDF]
, 2008 Ecological processes at the population and community level are often ignored in biogeochemical models, however, the effects of excluding these processes at the ecosystem level is uncertain. In this study we analyzed the set of behaviors that emerge after
Carlos A. Sierra, Mark E. Harmon
core +1 more source
Stand-replacing wildfires increase nitrification for decades in southwestern ponderosa pine forests. [PDF]
, 2014 Stand-replacing wildfires are a novel disturbance within ponderosa pine (Pinus ponderosa) forests of the southwestern United States, and they can convert forests to grasslands or shrublands for decades.
Fulé, Peter Z +4 more
core +2 more sources
Twenty years of post-fire plant succession in a "cerrado", São Carlos, SP, Brazil
Brazilian Journal of BiologySecondary succession in degraded areas is little studied, especially where long-term observation of evolutionary processes is concerned. The aim of this work was to follow the qualitative and quantitative changes in vegetation throughout the regeneration
J. J. Soares +2 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source