Results 131 to 140 of about 3,613,646 (331)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Smaller scale New Zealand dairy farmers: long term plans and key challenges [PDF]

, 2016
Farmer wellbeing has been defined as “a dynamic process that gives people a sense of how their lives are evolving” (Nimpagariste & Culver, 2010). In order to support and enhance the wellbeing of farmers in New Zealand, the farmers’ goals, future plans ...
Nuthall, Peter, Phillips, Tom, Westbrooke, Victoria   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Leaf trait networks shift toward high modularity during the succession of a subtropical forest, in southwest China

Ecological Indicators
During the process of forest succession, coexisting plant species fulfill diverse functions by modifying the interrelationships among functional traits.
Xuenan Li, Zhongfei Li, Zhixiong Xu, Zhiyun Lu, Zexin Fan, Yajun Chen, Shubin Zhang   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Secondary succession in a Swiss mire after a bog burst [PDF]

, 2018
Severe natural disturbances can lead to the recovery of the original vegetation or the shift to new vegetation types. While post-disturbance succession is well documented for regularly disturbed ecosystems, little is known about the pathways and rapidity
Feldmeyer-Christe, Elizabeth, Graf, Ulrich, Küchler, Meinrad   +2 more
core  

Success and Failure in Upper Secondary Education

Studia paedagogica, 2023
                 
Hlaďo, Petr, Novotný, Petr, Schuchart, Claudia   +2 more
openaire   +1 more source

Beta diversity subcomponents of plant species turnover and nestedness reveal drivers of community assembly in a regenerating subtropical forest

Ecology and Evolution
Secondary forests represent a significant proportion of global forest cover, with over 70% of forests in East Asia classified as regenerating. While succession has been studied extensively in temperate systems, trajectories of subtropical succession ...
Coskun Guclu, Chung‐Lim Luk, Louise Amy Ashton, Sawaid Abbas, Michael J. W. Boyle   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source