Results 161 to 170 of about 1,072 (251)

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg   +1 more
wiley   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout   +3 more
wiley   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

open access: yesDrug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum   +4 more
wiley   +1 more source

Transition Metal Compounds as Thermochromic Materials: Classification, Properties, Limitations, and Applications

open access: yesEcoEnergy, EarlyView.
This review systematically examines how different transition metal compounds—such as binary and multinary metal oxides, halides, sulfides, and salts—exhibit thermochromism based on the d‐electron configurations of their transition metal cations. It focuses on three main mechanisms of thermochromism: phase transition, charge transfer, and bandgap change.
Jie Wang   +5 more
wiley   +1 more source

A Perspective on Five‐Generation High‐Energy‐Density LiFePO4 Cathodes and Beyond: From Materials to Manufacturing

open access: yesEcoEnergy, EarlyView.
This perspective examines the evolution toward fifth‐generation LiFePO4. Practical volumetric energy density depends on preserving ionic transport, electronic connectivity, mechanical integrity, and active‐material utilization across powder design and manufacturing.
Xia Huang   +7 more
wiley   +1 more source

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