Results 221 to 230 of about 86,542 (275)
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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
Nature, 1999Bart De Strooper +2 more
exaly +2 more sources
Purification and cloning of amyloid precursor protein β-secretase from human brain
Nature, 1999Varghese John
exaly +2 more sources
Structural basis of Notch recognition by human γ-secretase
Nature, 2018Guanghui Yang, Rui Zhou, Qiang Zhou
exaly +2 more sources
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
Nature, 1999Riqiang Yan, Mark E Gurney
exaly +2 more sources
Selective Secretase Targeting for Alzheimer’s Disease Therapy
Journal of Alzheimer's Disease, 2021Alzheimer’s disease (AD) is associated with marked atrophy of the cerebral cortex and accumulation of amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by oligomers of amyloid-β (Aβ) in the brain, with a length of 42 and 40 amino ...
Alvaro Miranda +3 more
semanticscholar +1 more source
γ-Secretase inhibitors for breast cancer and hepatocellular carcinoma: From mechanism to treatment.
Life Science, 2021The γ-secretase complex is a key hydrolase for many type 1 transmembrane proteins. It is very important for activation of the Notch receptor and regulation of target-gene transcription.
Hui Jia +3 more
semanticscholar +1 more source
Recognition of the Amyloid Precursor Protein by Human gamma-secretase
, 2019Cleavage of amyloid precursor protein (APP) by the intramembrane protease γ-secretase is linked to Alzheimer's disease (AD). We report an atomic structure of human γ-secretase in complex with a transmembrane (TM) APP fragment at 2.6-angstrom resolution ...
R. Zhou +5 more
semanticscholar +1 more source
Biochemical Society Transactions, 2002
Development of Alzheimer's disease (AD) pathology appears to be causally related to age-dependent changes in the metabolism of the amyloid-β peptide (Aβ), leading to its enhanced aggregation and deposition.γ-Secretase is a crucial enzyme for the generation of Aβ from the amyloid-β precursor protein and thus represents a valid potential therapeutic ...
D. Beher, M. S. Shearman
openaire +1 more source
Development of Alzheimer's disease (AD) pathology appears to be causally related to age-dependent changes in the metabolism of the amyloid-β peptide (Aβ), leading to its enhanced aggregation and deposition.γ-Secretase is a crucial enzyme for the generation of Aβ from the amyloid-β precursor protein and thus represents a valid potential therapeutic ...
D. Beher, M. S. Shearman
openaire +1 more source
Dissecting γ‐secretase function
Journal of Neurochemistry, 2013Read the full article ‘Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ‐secretase’ on doi: 10.1111/jnc.12124.
openaire +2 more sources