Results 231 to 240 of about 86,542 (275)
Some of the next articles are maybe not open access.
Piperidine-derived γ-secretase modulators
Bioorganic & Medicinal Chemistry Letters, 2010This Letter details the SAR of a novel series of piperidine-derived gamma-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42, increase Abeta38 and have no effect on Abeta40 levels.
Adrian, Hall +7 more
openaire +2 more sources
Cryo-EM structure of gamma secretase in complex with a Notch fragment
, 2018Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unknown. Here we report the cryo-electron microscopy structure of human γ-secretase in complex with a Notch fragment at a ...
G. H. Yang +7 more
semanticscholar +1 more source
Biochemical Society transactions, 2003
Development of Alzheimer's disease (AD) pathology appears to be causally related to age-dependent changes in the metabolism of the amyloid-beta peptide (A beta), leading to its enhanced aggregation and deposition. gamma-Secretase is a crucial enzyme for the generation of A beta from the amyloid-beta precursor protein and thus represents a valid ...
D, Beher, M S, Shearman
openaire +1 more source
Development of Alzheimer's disease (AD) pathology appears to be causally related to age-dependent changes in the metabolism of the amyloid-beta peptide (A beta), leading to its enhanced aggregation and deposition. gamma-Secretase is a crucial enzyme for the generation of A beta from the amyloid-beta precursor protein and thus represents a valid ...
D, Beher, M S, Shearman
openaire +1 more source
Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Cell, 2021Guanghui Yang, Rui Zhou, Xuefei Guo
exaly
Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.
European journal of medicinal chemistry, 2018Devendra Kumar +5 more
semanticscholar +1 more source
Current Alzheimer research, 2005
Accumulation of the amyloid beta-peptide (Abeta) in the brain is believed to initiate a series of neurotoxic events that causes neurodegeneration in Alzheimer's disease (AD). Abeta is generated by processing of the beta-amyloid precursor protein (APP) through the successive action of two proteolytic enzymes, beta-secretase and gamma-secretase.
openaire +1 more source
Accumulation of the amyloid beta-peptide (Abeta) in the brain is believed to initiate a series of neurotoxic events that causes neurodegeneration in Alzheimer's disease (AD). Abeta is generated by processing of the beta-amyloid precursor protein (APP) through the successive action of two proteolytic enzymes, beta-secretase and gamma-secretase.
openaire +1 more source
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Nature, 2020Ji-Yeun Hur, Eitan Wong, Marilia Barros
exaly
γ-Secretase: proteasome of the membrane?
Nature Reviews Molecular Cell Biology, 2004Raphael Kopan, Ma Xenia G Ilagan
exaly