Results 161 to 170 of about 537,132 (265)

Transmembrane effector substrates of type IV secretion systems: mechanisms of secretion and insertion into host cell membranes. [PDF]

Microlife
Trenz SM, Kuwertz AK, Carl J, Wagner S.
europepmc   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation. [PDF]

Nat Microbiol
Young V, Dohai B, Halder H, Fernandez-Macgregor J, van Heusden NS, Hitch TCA, Weller B, Hyden P, Saha D, Pieren DKJ, Rittchen S, Lambourne L, Maseko SB, Lin CW, Tun YM, Bibus J, Pletschacher L, Boujeant M, Choteau SA, Bergogne L, Perrin J, Ober F, Schwehn P, Rothballer ST, Altmann M, Altmann S, Strobel A, Rothballer M, Tofaute M, Kotlarz D, Heinig M, Clavel T, Calderwood MA, Vidal M, Twizere JC, Vincentelli R, Krappmann D, Boes M, Falter C, Rattei T, Brun C, Zanzoni A, Falter-Braun P.   +42 more
europepmc   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Minor hemolysin-coregulated proteins (Hcp) form heteromeric complexes and mediate effector secretion in Bacteroidales type VI secretion systems. [PDF]

J Biol Chem
San-Miguel SG, Hillier JB, Saleh Al-Ammari MK, Johansson E, Kowalska A, Sauer U, Batista PR, Sandblad L, Uhlin BE, Cisneros DA.   +9 more
europepmc   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Unraveling the genomic complexity of secretion systems in the most virulent Xanthomonas arboricola pathovars. [PDF]

PLoS One
Cuesta-Morrondo S, Garita-Cambronero J, Cubero J.   +2 more
europepmc   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Secretins of type-two secretion systems are necessary for exopolymeric slime secretion in cyanobacteria and myxobacteria. [PDF]

Nat Commun
Zuckerman DM, So JMT, Hoiczyk E.
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source