Results 1 to 10 of about 8,552 (215)

Initiation of H1-T6SS dueling between Pseudomonas aeruginosa

MBio
The Type VI secretion system (T6SS) is a multicomponent apparatus, present in many Gram-negative bacteria, which can inhibit bacterial prey in various ecological niches.
Marek Basler, Alejandro Tejada Arranz, Sharath Narayanan   +2 more
exaly   +5 more sources

Functional characterization of a pore-forming effector TseMt from the H4 type VI secretion system of <i>Pseudomonas aeruginosa</i>. [PDF]

mLife
Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through comparative genomics, but their functions and effector biology remain ...
Wu L, Liu Y, Huang R, Zhao Y, Liu J, An Y, Zhang Y, Wang X, Zheng H, Pei T, Liang X, Liu X, Zheng M, Liu R, Li Y, Qu J, Liu Y, Yang L, Zhang M, Dong T.   +19 more
europepmc   +2 more sources

Functional diversity of accessory factors of the type VI secretion system [PDF]

Journal of Bacteriology
The type VI secretion system (T6SS) is a nanomachine utilized by Gram-negative bacteria to secrete toxic effectors. The T6SS is employed against both prokaryotic and eukaryotic targets, allowing for competitive advantage and virulence of the attackers in
Casey Latario, Benjamin D. Ross
doaj   +2 more sources

Genome-Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus. [PDF]

Microbiologyopen
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Duque M, Jacquemin A, Girlich D, Bonnin RA, Dortet L.   +4 more
europepmc   +2 more sources

Type VI secretion system degeneration accelerates intestinal epithelial cell death in Escherichia coli O157:H7. [PDF]

PLoS Pathogens
The type VI secretion system (T6SS) is a specific protein secretion apparatus that contributes to bacterial virulence. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) harbors multiple prophages and can cause severe human diseases worldwide.
Zhibin Sun, Chao Dong, Pengcheng Zhou, Quanquan Guan, Zhongli Cui, Yankai Xia, Yu-Feng Yao   +6 more
doaj   +2 more sources

Molecular epidemiology and clinical characteristics of the type VI secretion system in Klebsiella pneumoniae causing abscesses

Frontiers in Microbiology, 2023
PurposeThe type VI system (T6SS) has the potential to be a new virulence factor for hypervirulent Klebsiella pneumoniae (hvKp) strains. This study aimed to characterize the molecular and clinical features of T6SS-positive and T6SS-negative K.
Peilin Liu, Awen Yang, Bin Tang, Zhiqian Wang, Zijuan Jian, Yanjun Liu, Jiahui Wang, Jiahui Wang, Baiyun Zhong, Qun Yan, Wenen Liu, Wenen Liu   +11 more
doaj   +1 more source

The Interface of Vibrio cholerae and the Gut Microbiome

Gut Microbes, 2021
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. The gut microbiome, or the native community of microorganisms found in the human gastrointestinal tract, is increasingly being recognized as a factor in ...
Jennifer Y. Cho, Rui Liu, John C. Macbeth, Ansel Hsiao   +3 more
doaj   +1 more source

Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. [PDF]

PLoS ONE, 2013
Three Type VI Secretion System (T6SS) loci called H1- to H3-T6SS coexist in Pseudomonas aeruginosa. H1-T6SS targets prokaryotic cells whereas H2-T6SS mediates interactions with both eukaryotic and prokaryotic host cells.
Thibault G Sana, Chantal Soscia, Céline M Tonglet, Steve Garvis, Sophie Bleves   +4 more
doaj   +1 more source

Dual expression profile of type VI secretion system immunity genes protects pandemic Vibrio cholerae. [PDF]

PLoS Pathogens, 2013
The Vibrio cholerae type VI secretion system (T6SS) assembles as a molecular syringe that injects toxic protein effectors into both eukaryotic and prokaryotic cells. We previously reported that the V.
Sarah T Miyata, Daniel Unterweger, Sydney P Rudko, Stefan Pukatzki   +3 more
doaj   +1 more source

An Important Role of the Type VI Secretion System of Pseudomonas aeruginosa Regulated by Dnr in Response to Anaerobic Environments

Microbiology Spectrum, 2022
The type VI secretion system (T6SS) is capable of secreting a variety of metal-binding proteins involved in metal ion uptake, and it mediates an active metal ion transport system that contributes to competition between bacteria. Pseudomonas aeruginosa H2-
Jing Dang, Tietao Wang, Jing Wen, Haihua Liang   +3 more
doaj   +1 more source