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Repression of the Type VI Secretion System (T6SS) During Biofilm Formation Provides a Fitness Advantage for Vibrio cholerae [PDF]

Microorganisms
The type VI secretion system (T6SS) is a contact-dependent bacterial weapon to inject hazardous proteins into competitors and can be pivotal for bacterial fitness.
Stephan P. Ebenberger, Joao P. Pombo, Alexander Rechberger, Dominik Fleischhacker, Stefan Schild   +4 more
doaj   +2 more sources

Regulation of Type VI Secretion Systems of Burkholderia during transition to intracellular lifestyle [PDF]

EMBO Reports
Pathogenic bacteria tightly regulate gene expression in response to environmental cues. In Burkholderia species, the Type VI Secretion Systems (T6SS) mediate interbacterial competition and host cell interactions. Here, we show that B.
Hoi Ching Cheung, Daria Jacqueline Wüst, Miro Thorsten Wilhelm Plum, Patricia Reist Iscar, Marek Basler   +4 more
doaj   +2 more sources

Functional diversity of accessory factors of the type VI secretion system [PDF]

Journal of Bacteriology
The type VI secretion system (T6SS) is a nanomachine utilized by Gram-negative bacteria to secrete toxic effectors. The T6SS is employed against both prokaryotic and eukaryotic targets, allowing for competitive advantage and virulence of the attackers in
Casey Latario, Benjamin D. Ross
doaj   +2 more sources

ClpV3 Of the H3-Type VI Secretion System (H3-T6SS) Affects Multiple Virulence Factors in Pseudomonas aeruginosa

Frontiers in Microbiology, 2020
The type VI secretion system (T6SS) is a toxic effector delivery apparatus widely distributed in Gram-negative bacteria. The opportunistic pathogen Pseudomonas aeruginosa encodes three T6SSs, namely H1-, H2-, and H3-T6SS.
Anjali Y Bhagirath, Yanqi Li, Kangmin Duan   +2 more
exaly   +3 more sources

Molecular epidemiology and clinical characteristics of the type VI secretion system in Klebsiella pneumoniae causing abscesses

Frontiers in Microbiology, 2023
PurposeThe type VI system (T6SS) has the potential to be a new virulence factor for hypervirulent Klebsiella pneumoniae (hvKp) strains. This study aimed to characterize the molecular and clinical features of T6SS-positive and T6SS-negative K.
Peilin Liu, Awen Yang, Bin Tang, Zhiqian Wang, Zijuan Jian, Yanjun Liu, Jiahui Wang, Jiahui Wang, Baiyun Zhong, Qun Yan, Wenen Liu, Wenen Liu   +11 more
doaj   +1 more source

The Interface of Vibrio cholerae and the Gut Microbiome

Gut Microbes, 2021
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease cholera. The gut microbiome, or the native community of microorganisms found in the human gastrointestinal tract, is increasingly being recognized as a factor in ...
Jennifer Y. Cho, Rui Liu, John C. Macbeth, Ansel Hsiao   +3 more
doaj   +1 more source

Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. [PDF]

PLoS ONE, 2013
Three Type VI Secretion System (T6SS) loci called H1- to H3-T6SS coexist in Pseudomonas aeruginosa. H1-T6SS targets prokaryotic cells whereas H2-T6SS mediates interactions with both eukaryotic and prokaryotic host cells.
Thibault G Sana, Chantal Soscia, Céline M Tonglet, Steve Garvis, Sophie Bleves   +4 more
doaj   +1 more source

Dual expression profile of type VI secretion system immunity genes protects pandemic Vibrio cholerae. [PDF]

PLoS Pathogens, 2013
The Vibrio cholerae type VI secretion system (T6SS) assembles as a molecular syringe that injects toxic protein effectors into both eukaryotic and prokaryotic cells. We previously reported that the V.
Sarah T Miyata, Daniel Unterweger, Sydney P Rudko, Stefan Pukatzki   +3 more
doaj   +1 more source

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent.

PLoS Pathogens, 2020
Klebsiella pneumoniae is recognized as an urgent threat to human health due to the increasing isolation of multidrug resistant strains. Hypervirulent strains are a major concern due to their ability to cause life-threating infections in healthy hosts ...
Daniel Storey, Alan McNally, Mia Åstrand, Joana Sa-Pessoa Graca Santos, Isabel Rodriguez-Escudero, Bronagh Elmore, Leyre Palacios, Helina Marshall, Laura Hobley, Maria Molina, Victor J Cid, Tiina A Salminen, Jose A Bengoechea   +12 more
doaj   +1 more source

An Important Role of the Type VI Secretion System of Pseudomonas aeruginosa Regulated by Dnr in Response to Anaerobic Environments

Microbiology Spectrum, 2022
The type VI secretion system (T6SS) is capable of secreting a variety of metal-binding proteins involved in metal ion uptake, and it mediates an active metal ion transport system that contributes to competition between bacteria. Pseudomonas aeruginosa H2-
Jing Dang, Tietao Wang, Jing Wen, Haihua Liang   +3 more
doaj   +1 more source