Results 21 to 30 of about 8,918 (214)

An Overview of Anti-Eukaryotic T6SS Effectors [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine employed by many Gram-negative bacterial species to translocate, in a contact-dependent manner, effector proteins into adjacent prokaryotic or eukaryotic cells. Typically, the T6SS gene cluster encodes at least 13 conserved core components for the apparatus assembly and ...
Monjaras Feria, Julia, Valvano, Miguel A.   +1 more
openaire   +6 more sources

Functional characterization of a pore-forming effector TseMt from the H4 type VI secretion system of <i>Pseudomonas aeruginosa</i>. [PDF]

mLife
Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through comparative genomics, but their functions and effector biology remain ...
Wu L, Liu Y, Huang R, Zhao Y, Liu J, An Y, Zhang Y, Wang X, Zheng H, Pei T, Liang X, Liu X, Zheng M, Liu R, Li Y, Qu J, Liu Y, Yang L, Zhang M, Dong T.   +19 more
europepmc   +2 more sources

T6SS: A Key to Pseudomonas’s Success in Biocontrol?

Microorganisms, 2023
Bacteria from the genus Pseudomonas have been extensively studied for their capacity to act as biological control agents of disease and pests and for their ability to enhance and promote crop production in agricultural systems. While initial research primarily focused on the human pathogenic bacteria Pseudomonas aeruginosa, recent studies indicate the ...
Edwin D. Navarro-Monserrat, Christopher G. Taylor   +1 more
openaire   +3 more sources

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control. [PDF]

Biotechnol Bioeng
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Asemoloye MD.
europepmc   +2 more sources

T6SS

, 2023
Automated analysis of type 6 secretion system battles with FAST. Contains data of P. aeruginosa fighting with either WT V. cholerae (WT_VC_1 and WT_VC_2) or a knock-out with an inactivated T6SS (KO_VC_1 and KO_VC_2).
Oliver Meacock (14277698)
core   +1 more source

Engineering a customizable antibacterial T6SS-based platform in Vibrio natriegens [PDF]

The EMBO Reports, 2021
ABSTRACT Bacterial pathogens are a major risk to human, animal, and plant health. To counteract the spread of antibiotic resistance, alternative antibacterial strategies are urgently needed. Here, we constructed a proof-of-concept customizable, modular, and inducible antibacterial toxin delivery platform.
Jana, Biswanath, Keppel, Kinga, Salomon, Dor   +2 more
openaire   +2 more sources

Identification of A Putative T6SS Immunity Islet in Salmonella Typhi [PDF]

Pathogens, 2020
Typhoid fever is a major global health problem and is the result of systemic infections caused by the human-adapted bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi). The pathology underlying S. Typhi infections significantly differ from infections caused by broad host range serovars of the same species, which are a common cause of ...
Luke Barretto, Casey Fowler
openaire   +3 more sources

Identification of a functional type VI secretion system in Campylobacter jejuni conferring capsule polysaccharide sensitive cytotoxicity. [PDF]

PLoS Pathogens, 2013
The pathogen Campylobacter jejuni is the principal cause of bacterial food-borne infections. The mechanism(s) that contribute to bacterial survival and disease are still poorly understood.
Nancy M C Bleumink-Pluym, Lieke B van Alphen, Lieneke I Bouwman, Marc M S M Wösten, Jos P M van Putten   +4 more
doaj   +1 more source

Genome Wide Identification, Characterization and Evolutionary Analysis of T6SS in Burkholderia cenocepacia Strains [PDF]

International Journal Bioautomation
Pathogens of the Burkholderia genus are causing diseases in a diverse variety of hosts. After the discovery of T6SS, it was found to play a pivotal role in virulence and other pathogenicity factors in different pathogenic Burkholderia species.
Sardarni K. Raza, Muhammad Ibrahim, Kainaat, Afshan Farid, Sardar S. N. Khan, Aqsa Talat, Tayyaba Arzoo, Syeda I. Fatima, Abdul Waheed   +8 more
doaj   +1 more source

A Vibrio T6SS-Mediated Lethality in an Aquatic Animal Model

Microbiology Spectrum, 2023
The rise in sea surface temperature has been linked to the spread of bacteria belonging to the genus Vibrio and the human illnesses associated with them. Since vibrios often share virulence traits horizontally, a better understanding of their virulence potential and determinants can prepare ...
Hadar Cohen, Chaya M. Fridman, Motti Gerlic, Dor Salomon   +3 more
openaire   +3 more sources