RpoN/Sfa2-dependent activation of the Pseudomonas aeruginosa H2-T6SS and its cognate arsenal of antibacterial toxins. [PDF]
, 2021 Pseudomonas aeruginosa uses three type six secretion systems (H1-, H2- and H3-T6SS) to manipulate its environment, subvert host cells and for microbial competition.
Allsopp, Luke P +9 more
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The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae
Infection and Drug Resistance, 2023 Wenke Liu,1,* Min Li,1,* Shiwen Cao,1 Hafiz Muhammad Ishaq,2 Huajie Zhao,1 Fan Yang,1 Liang Liu1 1Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Faculty of ...
Liu W +6 more
doaj
A modular effector with a DNase domain and a marker for T6SS substrates [PDF]
Nature Communications, 2019 AbstractBacteria deliver toxic effectors via type VI secretion systems (T6SSs) to dominate competitors, but the identity and function of many effectors remain unknown. Here we identify a Vibrio antibacterial T6SS effector that contains a previously undescribed, widespread DNase toxin domain that we call PoNe (Polymorphic Nuclease effector).
Biswanath Jana +3 more
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Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in Agrobacterium tumefaciens. [PDF]
PLoS Pathogens, 2012 The type VI secretion system (T6SS) is a widespread, versatile protein secretion system in pathogenic Proteobacteria. Several T6SSs are tightly regulated by various regulatory systems at multiple levels.
Chih-Feng Wu +3 more
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T6SS: The bacterial “Fight Club” in the host gut
PLOS Pathogens, 2017 The mammalian gut is home to a densely populated community of microorganisms that not only provide their host with nutritional benefits but also offer protection against foreign pathogens. Since the gut is an environment limited in both space and nutrients, these microbes have evolved multiple mechanisms and strategies to either coexist or compete with
Thibault G. Sana +2 more
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NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa
Microbiology Spectrum, 2022 NrtR is a Nudix-related transcriptional regulator and controls the NAD cofactor biosynthesis in bacteria. P. aeruginosa NrtR binds to the intergenic region between nadD2 and pncA to repress the expression of the two operons, therefore controlling the NAD biosynthesis ...
Xinxin Zhang +9 more
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T6SS Accessory Proteins, Including DUF2169 Domain-Containing Protein and Pentapeptide Repeats Protein, Contribute to Bacterial Virulence in T6SS Group_5 of Burkholderia glumae BGR1 [PDF]
Plants, 2021 Burkholderia glumae are bacteria pathogenic to rice plants that cause a disease called bacterial panicle blight (BPB) in rice panicles. BPB, induced by B. glumae, causes enormous economic losses to the rice agricultural industry. B. glumae also causes bacterial disease in other crops because it has various virulence factors, such as toxins, proteases ...
Kim, Namgyu +5 more
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mBio, 2022 The human pathogen Vibrio cholerae grows as biofilms, communities of cells encased in an extracellular matrix. When growing in biofilms, cells compete for resources and space.
Jennifer K. Teschler +8 more
doaj +1 more source
Type VI secretion system : secretion by a contractile nanomachine [PDF]
, 2015 The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is
Basler, Marek, Basler M
core +1 more source
Differential Role of the T6SS in Acinetobacter baumannii Virulence
PLOS ONE, 2015 Las bacterias gramnegativas, como Acinetobacter baumannii, son una carga cada vez mayor en los hospitales de todo el mundo con una propagación alarmante de cepas multirresistentes (MDR). Aquí, comparamos una cepa tipo (ATCC17978), un aislado no clínico (DSM30011) y cepas MDR de A.
Guillermo D. Repizo +8 more
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