Results 201 to 210 of about 546,603 (232)

Homozygous Expression of a Missense Mutation at Nucleotide 385 in the FUT2 Gene Associates With the Le(a+b+) Partial-Secretor Phenotype in an Indonesian Family

Biochemical and Biophysical Research Communications, 1996
A new point mutation was found in the coding sequence of the secretor FUT2 gene. This missense mutation with an A-->T substitution at nucleotide 385 resulted in an amino acid change of Ile129 to Phe129. This mutation showed a clear genetic trait in an Indonesian pedigree and, when appearing in a homozygous form, it was associated with the red cell Le(a+
Göran Larson, Stephen Henry, Rafael Oriol   +2 more
exaly   +3 more sources

Gut Microbiome Composition and Metabolic Capacity Differ by FUT2 Secretor Status in Exclusively Breastfed Infants

Nutrients, 2023
A major polymorphism in the fucosyltransferase2 (FUT2) gene influences risk of multiple gut diseases, but its impact on the microbiome of breastfed infants was unknown.
David B Haslam
exaly   +2 more sources

ABH Secretor Genetic Polymorphism: Evidence of Intrauterine Selection

European Journal of Obstetrics, Gynecology and Reproductive Biology, 2011
Fucosyltransferase locus 2 (FUT2) controls the presence or absence of blood group substances (A, B, H) in the saliva and other body secretions. Secretor/non-secretor phenotypes are associated with some metabolic and infectious diseases.
Antonio Pietroiusti, Andrea Magrini, A Amante   +2 more
exaly   +2 more sources

An Association Between LSIL and the High Secretor Phenotype of IL-1β

Gynecologic Oncology, 1999
The aims of this study were to determine the frequency of a nucleotide transition from C to T, which leads to increased transcription of interleukin-1beta (IL-1beta) in patients with different grades of cervical lesions, and to determine whether a correlation exists between the genotypes and cervical lesions.One hundred forty-seven DNA samples from ...
G S, Majeed, S, Glew, J, Bidwell
openaire   +2 more sources

Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype

The Journal of Pathology, 2008
AbstractHelicobacter pylori (Hp) infects half the world's population and causes diverse gastric lesions, from gastritis to gastric cancer. Our aim was to evaluate the significance of secretor and Lewis status in infection and in vitro adherence by Hp expressing BabA adhesin. We enrolled 304 Hp‐infected individuals from Northern Portugal.
M, Azevedo, S, Eriksson, N, Mendes, J, Serpa, C, Figueiredo, L P, Resende, N, Ruvoën-Clouet, R, Haas, T, Borén, J, Le Pendu, L, David   +10 more
openaire   +2 more sources

AN INTERLUEKIN 1B ALLELE, WHICH CORRELATES WITH A HIGH SECRETOR PHENOTYPE, IS ASSOCIATED WITH DIABETIC NEPHROPATHY

Cytokine, 1998
Induction of interleukin 1 activates vascular endothelial and kidney mesangial cells, and increases production of type IV (basement membrane) collagen. Hence, genes within the interleukin 1 gene cluster are potential candidates in the pathogenesis of diabetic nephropathy. In a previously validated case-control study from Northern Ireland, consisting of
B V, Loughrey, A P, Maxwell, D G, Fogarty, D, Middleton, J C, Harron, C C, Patterson, C, Darke, D A, Savage   +7 more
openaire   +3 more sources

ABH secretor status, as judged by the Lewis phenotypes, in Norwegian survivors from meningococcal disease

APMIS, 1993
Survivors from meningococcal disease (serogroups B and C) and a control series (blood donors) were examined for their ability to secrete ABH blood group substance. The examination was done indirectly by determining their Lewis phenotypes. There was no significant difference in the secretor status between the two groups.
L, Kornstad, A L, Heistøo, T E, Michaelsen, G, Bjune   +3 more
openaire   +2 more sources

Identification of Leb antigens in meconium of a phenotypically a Le(a+b−) non-secretor individual

Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
Blood group active fucolipids of human meconium have been shown to correlate to the ABH and Lewis blood groups and to the secretor status of the corresponding children. Using a monoclonal anti-Leb antibody and an antibody to chromatogram binding assay the presence of Leb antigens in meconium of a phenotypically A Le(a+ b-) non-secretor individual is ...
openaire   +2 more sources

Soluble type A substance in fresh-frozen plasma as a function of ABO and Secretor genotypes and Lewis phenotype

Transfusion and Apheresis Science, 2005
Soluble ABO blood group substance (SAS) in fresh-frozen plasma (FFP) and its cognate alloantibody titer reduction capacity (TRC) are not considered when prescribing this product for plasma exchange (PEX) therapy of ABO incompatible transplant recipients. SAS was quantified in 250 single FFPs using ELISA. Total and IgG class-specific anti-A TRCs of FFPs
Achermann FJ, Julmy F, Gilliver LG, Carrel TP, Nydegger UE   +4 more
openaire   +3 more sources

Serological and secretor status analysis of Am phenotypes: Two cases from Northeast India

Transfusion and Apheresis Science
In ABO blood grouping, a type II discrepancy refers to weak or absent antigen reactions in cell grouping, often indicating a weak ABO subgroup. The Am phenotype is a rare weak A subgroup variant, distinguished by absent agglutination with anti-A antisera and normal A substance in saliva.
Joyisa Deb, Priyanka Gogoi, Gopal Krushna Ray, Samim Sultana Hoque   +3 more
openaire   +2 more sources