Results 1 to 10 of about 18,346 (158)

Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis [PDF]

Clinical Infectious Diseases, 2021
Abstract In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri.
Jhansi L Leslie, Erin Weddle, Jennie Z
exaly   +5 more sources

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis

FEBS Open Bio, 2022
Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection.
Tomomi Kimura‐Someya, Miyuki Kato‐Murayama, Kazushige Katsura, Naoki Sakai, Kazutaka Murayama, Kazuharu Hanada, Mikako Shirouzu, Yuichi Someya   +7 more
doaj   +2 more sources

Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study [PDF]

Journal of Pediatrics: Clinical Practice
Objective: We investigated if specific carbohydrate blood group antigens were associated with infant botulism (IB) among discordant twins and triplets.
Haydee A. Dabritz, PhD, Mayuri V. Panditrao, PhD, MPH, Suchitra Pandey, MD, Nir Dover, PhD, Jason R. Barash, CLS, MT(ASCP), Jessica M. Khouri, MD, Jennifer S. Read, MD, MS, MPH   +6 more
doaj   +2 more sources

The ABO, Lewis and related blood group antigens; a review of structure and biosynthesis [PDF]

FEMS Microbiology Letters, 1989
Numerous studies have shown that the antigenic determinants of the ABO blood group system are closely related in biochemical terms to the antigenic determinants of the Hh, P, Lewis and Ii blood group systems. The blood group antigens of each of these systems are formed by the addition of specific sugars to an oligosaccharide precursor chain which may ...
C Green
exaly   +3 more sources

Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals [PDF]

Blood, 1991
The Lewis blood group system comprises two main carbohydrate antigens, Le(a) and Le(b). Lewis typing has traditionally been based on serologic determinations using erythrocytes and saliva. Several recent studies have demonstrated that erythrocyte Lewis phenotype may change during pregnancy or disease, and inappropriate Lewis antigens have been found in
Henrik Clausen, Johnson P, Hakomori S
exaly   +4 more sources

Importance of Phenotyping Minor Blood Group Antigen in Renal Transplant Donors: A Retrospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Various studies have implicated minor antigens with increased graft rejection in the long term, especially in alloimmunised patients. Recipient’s antibody testing is done exhaustively during each case of rejection. However, without data
Sujata Mallick, Mahasweta Mallik, Puskar Shyam Chowdhury   +2 more
doaj   +1 more source

Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. [PDF]

PLoS Neglected Tropical Diseases, 2011
Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric infections.
Mohammad Arifuzzaman, Tanvir Ahmed, Mohammad Arif Rahman, Fahima Chowdhury, Rasheduzzaman Rashu, Ashraful I Khan, Regina C LaRocque, Jason B Harris, Taufiqur Rahman Bhuiyan, Edward T Ryan, Stephen B Calderwood, Firdausi Qadri   +11 more
doaj   +1 more source

The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population. [PDF]

PLoS ONE, 2013
BACKGROUND: The Lewis (FUT3) gene is responsible for the expression of the Le(a) and Le(b) blood group antigens. The individuals, who not synthesize these antigens have the phenotype Lewis negative, due to the presence of some single nucleotide ...
Tereza Cristina de Oliveira Corvelo, Rosane do Socorro Pompeu de Loiola, Délia Cristina Figueira Aguiar, Gyselly de Cássia Bastos de Matos, Danielle Calado de Brito   +4 more
doaj   +1 more source

The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2021
The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues.
Luiz Carlos De Mattos, Ana Iara Costa Ferreira, Karina Younan de Oliveira, Fabiana Nakashima, Cinara Cássia Brandão, Cinara Cássia Brandão   +5 more
doaj   +1 more source

Lewis b antigen is a common ligand for genogroup I norovirus strains

FEBS Open Bio, 2022
Noroviruses are major causative agents of nonbacterial acute gastroenteritis in humans. Ten genogroups of noroviruses have been identified to date, among which genogroup I (GI) and genogroup II (GII) noroviruses are major pathogens for humans. GI and GII
Yuichi Someya
doaj   +1 more source