Results 31 to 40 of about 18,410 (222)

Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon

Genetics and Molecular Biology, 2007
The Lewis blood group system involves two major antigens, Leª and Le b. Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of ...
Pablo Abdon da Costa Francez, Tereza Cristina de Oliveira Corvelo, Flávio Ricardo Leal da Silva, Sidney Emanuel Batista dos Santos   +3 more
doaj   +1 more source

Extent of the protection afforded by histo-blood group polymorphism against rotavirus gastroenteritis in metropolitan France and French Guiana

Frontiers in Microbiology, 2023
Human rotaviruses attach to histo-blood group antigens glycans and null alleles of the ABO, FUT2 and FUT3 genes seem to confer diminished risk of gastroenteritis. Yet, the true extent of this protection remains poorly quantified.
Lydie Masson, Laure Barbé, Fanny Henaff, Tasnuva Ahmed, Tasnuva Ahmed, Béatrice Le Moullac-Vaidye, Cécile Peltier, Sarah S Marchand, Pauline Scherdel, Marie-Anne Vibet, Nathalie Ruvoën-Clouet, Nathalie Ruvoën-Clouet, Narcisse Elenga, Berthe-Marie Imbert-Marcille, Berthe-Marie Imbert-Marcille, Christèle Gras-Le Guen, Jacques Le Pendu   +16 more
doaj   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Emerging Infectious Diseases, 2015
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus.
Siwar Ayouni, Khira Sdiri-Loulizi, Alexis de Rougemont, Marie Estienney, Katia Ambert-Balay, Serge Aho, Sabeur Hamami, Mahjoub Aouni, Mohamed Neji-Guediche, Pierre Pothier, Gaël Belliot   +10 more
doaj   +1 more source

Host genetic factors affect susceptibility to norovirus infections in Burkina Faso. [PDF]

PLoS ONE, 2013
Norovirus (NoV) constitutes the second most common viral pathogen causing pediatric diarrhea after rotavirus. In Africa, diarrhea is a major health problem in children, and yet few studies have been performed regarding NoV. The association of histo-blood
Johan Nordgren, Léon W Nitiema, Djeneba Ouermi, Jacques Simpore, Lennart Svensson   +4 more
doaj   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Species-Specific N-Glycomes and Methylation Patterns of Oysters Crassostrea gigas and Ostrea edulis and Their Possible Consequences for the Norovirus–HBGA Interaction

Marine Drugs, 2023
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their host tissues. The
Audrey Auger, Shin-Yi Yu, Shih-Yun Guu, Agnès Quéméner, Gabriel Euller-Nicolas, Hiromune Ando, Marion Desdouits, Françoise S. Le Guyader, Kay-Hooi Khoo, Jacques Le Pendu, Frederic Chirat, Yann Guerardel   +11 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Losses of expression of the antigens A, Le^a and Le^x and over-expression of Le^y in carcinomas and HG-SIL of the uterine cervix

Diagnostic Pathology, 2008
Background The glycosylation of a great number of molecules, glyco-protein or glycolipids, has been of interest for decades. Objective To compare the expressive patterns of the isoantigenic determinants of histo-blood groups ABH and Lewis in squamous and
Álvarez-Fernández Emilio, Moro-Rodríguez Ernesto   +1 more
doaj   +1 more source

Association between histo-blood group antigens and Pseudomonas aeruginosa-associated diarrheal diseases

Journal of Microbiology, Immunology and Infection, 2023
Background: Pseudomonas aeruginosa is not a common enteric pathogen. The association between human histo-blood group antigens (HBGAs) and P. aeruginosa enteric infection has not yet been studied.
Chih-Hsien Chuang, Rajendra Prasad Janapatla, Yi-Hsin Wang, Hsin-Ju Chang, Chyi-Liang Chen, Cheng-Hsun Chiu   +5 more
doaj   +1 more source