Results 21 to 30 of about 18,410 (222)

Expression of Lewisa, Sialyl Lewisa, Lewisx, Sialyl Lewisx, Antigens as Prognostic Factors in Patients with Colorectal Cancer

Canadian Journal of Gastroenterology, 2000
BACKGROUND: Altered expression of blood group-related carbohydrate antigens such as sialyl Lewis (Le)x antigen in tumours is associated with tumour progression behaviour and subsequent prognosis.
Tohru Nakagoe, Kiyoyasu Fukushima, Atsushi Nanashima, Terumitsu Sawai, Takashi Tsuji, Masaaki Jibiki, Hiroyuki Yamaguchi, Toru Yasutake, Hiroyoshi Ayabe, Tatsuki Matuo, Yutaka Tagawa, Kokichi Arisawa   +11 more
doaj   +1 more source

Role of ABO secretor status in mucosal innate immunity and H. pylori infection.

PLoS Pathogens, 2008
The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of ...
Sara Lindén, Jafar Mahdavi, Cristina Semino-Mora, Cara Olsen, Ingemar Carlstedt, Thomas Borén, Andre Dubois   +6 more
doaj   +1 more source

Distribution characteristics of unexpected antibody in 1 779 patients and corresponding blood transfusion strategy

Zhongguo shuxue zazhi, 2022
Objective To observe the distribution of the unexpected antibodies in order to study the safety and strategies in 1 779 cases of clinical blood transfusion.
Liangzi ZHANG, Qinqin ZUO, Yong ZHANG, Dazhou WU, Weiwei ZHANG, Hong WANG, Xiaoyue CHU, Juan MAO, Hua XU   +8 more
doaj   +1 more source

Fluorescence Melting Curve Analysis for Concurrent Genotyping of Three Tag SNPs in FUT3

Diagnostics, 2022
The synthesis of Lewis blood group antigens is governed by two fucosyltransferase genes, FUT2 and FUT3. Evidence is accumulating to suggest that functional polymorphisms of FUT2 and FUT3 are associated with a variety of clinical conditions.
Mikiko Soejima, Yoshiro Koda
doaj   +1 more source

Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens. [PDF]

PLoS Pathogens, 2011
Noroviruses, an important cause of acute gastroenteritis in humans, recognize the histo-blood group antigens (HBGAs) as host susceptible factors in a strain-specific manner.
Yutao Chen, Ming Tan, Ming Xia, Ning Hao, Xuejun C Zhang, Pengwei Huang, Xi Jiang, Xuemei Li, Zihe Rao   +8 more
doaj   +1 more source

Helicobacter pylori and the Role of Lipopolysaccharide Variation in Innate Immune Evasion

Frontiers in Immunology, 2022
Helicobacter pylori is an important human pathogen that infects half the human population and can lead to significant clinical outcomes such as acute and chronic gastritis, duodenal ulcer, and gastric adenocarcinoma. To establish infection, H.
Daniel Sijmons, Andrew J. Guy, Andrew J. Guy, Anna K. Walduck, Paul A. Ramsland, Paul A. Ramsland, Paul A. Ramsland   +6 more
doaj   +1 more source

The prevalence of secretor status and co-expression of lewis antigen in voluntary blood donors

Asian Journal of Medical Sciences, 2016
Background: Blood group substances are present in soluble form in a majority of individuals in secretion such as saliva and body fl uids. Secretor status refers to the presence (SeSe and Sese) or absence (sese) of secretor gene which secrete ABH ...
R Raj Bharath
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source