Results 41 to 50 of about 13,859,648 (230)

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

open access: yesEmerging Infectious Diseases, 2015
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus.
Siwar Ayouni   +10 more
doaj   +1 more source

MetaPaCS: A Novel Meta‐Learning Framework for Pancreatic Cancer Subtype Identification

open access: yesAdvanced Intelligent Systems, EarlyView.
We have developed MetaPaCS, an ensemble meta‐learning framework for reliable prediction of pancreatic cancer subtypes with high accuracy. MetaPaCS is capable of capturing subtype‐specific distinct gene expression patterns and drug‐disease associations for pancreatic cancer.
Nick B. Peterson   +4 more
wiley   +1 more source

Final Analysis of the BRUIN Phase 1/2 Study Assessing the Safety and Efficacy of Pirtobrutinib Monotherapy in Patients With MCL

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib, a highly selective, non‐covalent Bruton tyrosine kinase inhibitor (BTKi) previously demonstrated durable efficacy and tolerable safety following covalent (c) BTKi therapy in heavily pretreated relapsed/refractory (R/R) mantle cell lymphoma (MCL).
Michael L. Wang   +36 more
wiley   +1 more source

Automated glycan assembly of Lewis type I and II oligosaccharide antigens [PDF]

open access: yes, 2019
Human blood group related glycan antigens are fucosylated (neo-)lactoseries oligosaccharides that playcrucial roles in pathogenic processes. Lewis type-II-chain antigens mark the surface of cancer cells, butare also mediators of bacterial infections.
Guberman, M.   +8 more
core   +1 more source

Distinct Consequences of BCOR and BCORL1 Mutations in Myeloid Neoplasms and Bone Marrow Failure

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT BCOR and BCORL1 (BCOR/L1) mutations are observed in both myeloid neoplasms (MN) and bone marrow failure syndromes (BMF), but their clinical significance may differ. We analyzed 11 340 patients and identified 418 BCOR/L1‐mutated patients, focusing on differences between MN and BMF. Compared with MN, BMF was associated with younger age, a higher
Atsushi Marumo   +23 more
wiley   +1 more source

Prevalence of Lewis Blood Group among Bangladeshi Population

open access: yes, 2017
Background: The Lewis system differs from all other blood group systems. It is primarily a system of soluble antigens originate in the tissue of body secretions, such as saliva (glycoprotein) and in plasma (glycolipid) respectively.The ABH secretor ...
Hafizur Rahman   +3 more
core   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

open access: yesAnimal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen   +7 more
wiley   +1 more source

Host genetic factors affect susceptibility to norovirus infections in Burkina Faso. [PDF]

open access: yesPLoS ONE, 2013
Norovirus (NoV) constitutes the second most common viral pathogen causing pediatric diarrhea after rotavirus. In Africa, diarrhea is a major health problem in children, and yet few studies have been performed regarding NoV. The association of histo-blood
Johan Nordgren   +4 more
doaj   +1 more source

Extent of the protection afforded by histo-blood group polymorphism against rotavirus gastroenteritis in metropolitan France and French Guiana

open access: yesFrontiers in Microbiology, 2023
Human rotaviruses attach to histo-blood group antigens glycans and null alleles of the ABO, FUT2 and FUT3 genes seem to confer diminished risk of gastroenteritis. Yet, the true extent of this protection remains poorly quantified.
Lydie Masson   +16 more
doaj   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

open access: yesInterdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang   +8 more
wiley   +1 more source

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