Results 61 to 70 of about 13,859,648 (230)

The O-Linked Glycome and Blood Group Antigens ABO on Mucin-Type Glycoproteins in Mucinous and Serous Epithelial Ovarian Tumors. [PDF]

PLoS ONE, 2015
Mucins are heavily O-glycosylated proteins where the glycosylation has been shown to play an important role in cancer. Normal epithelial ovarian cells do not express secreted mucins, but their abnormal expression has previously been described in ...
Varvara Vitiazeva, Jayesh J Kattla, Sarah A Flowers, Sara K Lindén, Pushpa Premaratne, Birgitta Weijdegård, Karin Sundfeldt, Niclas G Karlsson   +7 more
doaj   +1 more source

Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals [PDF]

Blood, 1991
The Lewis blood group system comprises two main carbohydrate antigens, Le(a) and Le(b). Lewis typing has traditionally been based on serologic determinations using erythrocytes and saliva. Several recent studies have demonstrated that erythrocyte Lewis phenotype may change during pregnancy or disease, and inappropriate Lewis antigens have been found in
T F, Orntoft, E H, Holmes, P, Johnson, S, Hakomori, H, Clausen   +4 more
openaire   +3 more sources

The Diagnosis and Prenatal Management of Non‐RHD Alloimmunizations

Prenatal Diagnosis, EarlyView.
ABSTRACT Red blood cell (RBC) alloimmunization remains a relevant cause of hemolytic disease of the fetus and newborn (HDFN). Although RhD immunization has significantly decreased since the implementation of systematic prophylaxis, it is still the main cause of alloimmunization in pregnancy.
Mar Bennasar, Antoni Borrell
wiley   +1 more source

ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

São Paulo Medical Journal
CONTEXT: Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers.
Luiz Carlos de Mattos, Juliana Rodrigues Cintra, Fábio Eduardo Sanches, Rita de Cássia Martins Alves da Silva, Milton Artur Ruiz, Haroldo Wilson Moreira   +5 more
doaj   +1 more source

Genetic Susceptibility to Human Norovirus Infection: An Update

Viruses, 2019
Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely
Johan Nordgren, Lennart Svensson
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Exploring the diverse biological significance and roles of fucosylated oligosaccharides

Frontiers in Molecular Biosciences
Long since, carbohydrates were thought to be used just as an energy source and structural material. However, in recent years, with the emergence of the field of glycobiology and advances in glycomics, much has been learned about the biological role of ...
Burcu Pekdemir, Sercan Karav
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Lewis histo-blood group alpha1,3/alpha1,4 fucose residues may both mediate binding to GII.4 noroviruses

, 2012
Human noroviruses cause recurrent epidemics of gastroenteritis known to be dominated by the clinically important GII.4 genotype which recognizes human Secretor gene-dependent ABH histo-blood group antigens (HBGAs) as attachment factors.
Frank, M., Larson, G.,, Koppisetty, Chaitanya A. K., Koppisetty, Chaitanya A. K.,, Koppisetty, Ashok Krishna Chaitanya,, Nyholm, Per-Georg, Nyholm, Per-Georg,, Frank, M.,, Larson, G., Koppisetty, Ashok Krishna Chaitanya, Nasir, Waqas,, Nasir, Waqas   +11 more
core   +1 more source

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source