Results 121 to 130 of about 1,746,741 (337)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

A Kähler Einstein structure on the tangent bundle of a space form

International Journal of Mathematics and Mathematical Sciences, 2001
We obtain a Kähler Einstein structure on the tangent bundle of a Riemannian manifold of constant negative curvature. Moreover, the holomorphic sectional curvature of this Kähler Einstein structure is constant.
Vasile Oproiu
doaj   +1 more source

Almost Kenmotsu $f$-manifolds

Karpatsʹkì Matematičnì Publìkacìï, 2015
In this paper, we consider a generalization of almost Kenmotsu f-manifolds. We get basic Riemannian curvature, sectional curvatures and scalar curvature properties such type manifolds. Finally, we give two examples to clarify some our results.
Y.S. Balkan, N. Aktan
doaj   +1 more source

Fluctuation of Sectional Curvature for Closed Hypersurfaces [PDF]

Rocky Mountain Journal of Mathematics, 2002
Let \(f: M\to (\mathbb{R}^{n+1},\text{can})\) be an immersion as a hypersurface of a smooth closed manifold \(M\) and denote by \(f^*\)can the pullback metric on \(M\) of the canonical metric can on \(\mathbb{R}^{n+1}\). If \(M\) is not diffeomorphic to \(S^n\), then the sectional curvature of \(M\) with respect to this metric cannot be constant and it
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Contravariant Curvatures of Doubly Warped Product Poisson Manifolds

Mathematics
In this paper, we investigate the sectional contravariant curvature of a doubly warped product manifold ( fB×bF,g˜,Π=ΠB+ΠF) equipped with a product Poisson structure Π, using warping functions and sectional curvatures of its factor manifolds (B,g˜B,ΠB ...
Foued Aloui, Shyamal Kumar Hui, Ibrahim Al-Dayel   +2 more
doaj   +1 more source

A Liouville Property of Holomorphic Maps

The Scientific World Journal, 2013
We prove a Liouville property of holomorphic maps from a complete Kähler manifold with nonnegative holomorphic bisectional curvature to a complete simply connected Kähler manifold with a certain assumption on the sectional curvature.
Chengjie Yu
doaj   +1 more source

Submanifolds of constant sectional curvature with parallel or constant mean curvature

Tohoku Mathematical Journal, 1993
We classify isometric immersions with flat normal bundle between spaces of constant sectional curvature if either the mean curvature is parallel or if the manifolds are complete Euclidean spaces and the mean curvature is of constant length.
Dajczer, Marcos, Tojeiro, Ruy
openaire   +3 more sources

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source