Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
The Magid-Ryan conjecture for equiaffine hyperspheres with constant sectional curvature [PDF]
, 2000 Luc Vrancken
openalex +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Einstein Hermitian metrics of positive sectional curvature
Proceedings of the American Mathematical Society, 2014 It is shown that, up to scaling and isometry, the only complete 4-manifold with an Einstein metric of positive sectional curvature which is also Hermitian with respect to some complex structure is the complex projective plane C P 2 \mathbb {CP}_2 , equipped with its Fubini-Study metric.
openaire +2 more sources
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Einstein manifolds of non-negative sectional curvature and entropy [PDF]
, 2000 Gabriel P. Paternain, Jimmy Petean
openalex +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz +3 more
wiley +1 more source
Optimal inequalities involving Casorati curvatures for Riemannian maps to nearly Kaehler manifolds
Journal of Inequalities and ApplicationsWe establish a general inequality and optimal inequalities involving the normalized Casorati curvatures and the generalized normalized Casorati curvatures within the horizontal space of a Riemannian map from a Riemannian manifold to a nearly Kaehler ...
Tanveer Fatima +5 more
doaj +1 more source