Results 41 to 50 of about 136,858 (207)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Mixed sectional-Ricci curvature obstructions on tori
, 2017 We establish new obstruction results to the existence of Riemannian metrics on tori satisfying mixed bounds on both their sectional and Ricci curvatures.
Kloeckner, Benoît, Sabourau, Stéphane
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Sectional Curvature of Connections with Vectorial Torsion
Russian Mathematics, 2020 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Klepikov, P. N. +2 more
openaire +3 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Cross Curvature Flow of 3-manifolds with Negative Sectional Curvature
, 2003 We introduce a geometric evolution equation for 3-manifolds with sectional curvature of one sign which is in some sense dual to the Ricci flow. On a closed 3-manifold with negative sectional curvature, we establish short time existence and a pair of monotonicity formulas for solutions to the flow. One of these formulas shows that, provided the solution
Chow, Bennett, Hamilton, Richard S.
openaire +3 more sources
On Complete Hypersurfaces of Nonnegative Sectional Curvatures and Constant mth Mean Curvatures [PDF]
Transactions of the American Mathematical Society, 1978 The main result is that if M = M n M = {M^n} is a complete Riemann manifold of nonnegative sectional curvature and X : M → R n + 1
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Casorati Inequalities for Statistical Submanifolds in Kenmotsu Statistical Manifolds of Constant ϕ-Sectional Curvature with Semi-Symmetric Metric Connection. [PDF]
Entropy (Basel), 2022 Decu S, Vîlcu GE.
europepmc +1 more source