Results 51 to 60 of about 1,568,392 (257)

A New Proof of a Conjecture on Nonpositive Ricci Curved Compact Kähler–Einstein Surfaces

open access: yesMathematics, 2018
In an earlier paper, we gave a proof of the conjecture of the pinching of the bisectional curvature mentioned in those two papers of Hong et al. of 1988 and 2011. Moreover, we proved that any compact Kähler–Einstein surface M is a quotient of the complex
Zhuang-Dan Daniel Guan
doaj   +1 more source

Normal form of the NK-curvature operators [PDF]

open access: yes, 1964
summary:In this paper we classify real hypersurfaces with constant totally real bisectional curvature in a non flat complex space form $M_m(c)$, $c\ne 0$ as those which have constant holomorphic sectional curvature given in [6] and [13] or constant ...
Pérez, Juan de Dios   +6 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Some Applications of Casorati Curvature for Statistical Submanifolds of Sasakian Statistical Manifolds and Locally Homogeneous, Quasi-Umbilical Hypersurfaces

open access: yesپژوهش‌های ریاضی, 2021
In this paper, in the first part, the affine geometry is assumed as the main framework. Then we have a spacious explanation of necessary introduction in rather different subjects.
Azam Etemad Dehkordy
doaj  

Totally real submanifolds with nonnegative sectional curvature

open access: yes, 1986
We prove that an n n -dimensional compact totally real submanifold immersed in an n n -dimensional complex space form with parallel mean curvature vector and nonnegative sectional curvature has parallel second ...
Yoshihiro Ohnita
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Sectional curvature of standard static space-times [PDF]

open access: yes, 2013
Cataloged from PDF version of article.Includes bibliographical references leaves 45-47.Curvature related geometric properties of warped product manifolds are given. The casual structure of Lorentzian warped products is reviewed.
Yavuz, Bengi Ruken
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

A Novel Approach for Evaluating Seismic Performance of Frame-Type Underground Structures

open access: yesBuildings
This paper examines the seismic performance evaluation methodology for underground structures. Through analysis of seismic damage and failure characteristics of underground structures, this study proposes a novel evaluation approach for frame-type ...
Zhong-Yang Yu   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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