Results 71 to 80 of about 28,343 (263)

Curvature and topology dependency of the cosmological spectra

Results in Physics, 2019
In this article we investigate dependency of two important cosmological random fields defined on spatial slices of the FLRW universe and their spectra on the geometry and topology of the background universe.
Ali A. Asgari, Amir H. Abbassi, Jafar Khodagholizadeh   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

SYMMETRIES OF SECTIONAL CURVATURE ON 3-MANIFOLDS

Demonstratio Mathematica, 1995
The authors determine the possible symmetry groups for the sectional curvature \(K\) of a smooth 3-manifold with a Lorentzian metric tensor (giving complete details) and with a Riemannian metric tensor (omitting details). They study the existence of naturally reductive spaces in which the symmetry group of \(K\) is the same at every point.
Cordero, Luis A., Parker, Phillip E.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A basic inequality for submanifolds in a cosymplectic space form

International Journal of Mathematics and Mathematical Sciences, 2003
For submanifolds tangent to the structure vector field in cosymplectic space forms, we establish a basic inequality between the main intrinsic invariants of the submanifold, namely, its sectional curvature and scalar curvature on one side; and its main ...
Jeong-Sik Kim, Jaedong Choi
doaj   +1 more source

The L-sectional curvature of S-manifolds

, 2013
Ministerio de Economía y ...
AKYOL, Mehmet Akif, FERNANDEZ,, Luis M., PRIETO-MARTIN, Alicia   +2 more
openaire   +5 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A Kähler Einstein structure on the tangent bundle of a space form

International Journal of Mathematics and Mathematical Sciences, 2001
We obtain a Kähler Einstein structure on the tangent bundle of a Riemannian manifold of constant negative curvature. Moreover, the holomorphic sectional curvature of this Kähler Einstein structure is constant.
Vasile Oproiu
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Almost Kenmotsu $f$-manifolds

Karpatsʹkì Matematičnì Publìkacìï, 2015
In this paper, we consider a generalization of almost Kenmotsu f-manifolds. We get basic Riemannian curvature, sectional curvatures and scalar curvature properties such type manifolds. Finally, we give two examples to clarify some our results.
Y.S. Balkan, N. Aktan
doaj   +1 more source