Results 41 to 50 of about 28,343 (263)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Chern Sectional Curvature of a Hermitian Manifold
, 2022 On a Hermitian manifold, the Chern connection can induce a metric connection on the background Riemannian manifold. We call the sectional curvature of the metric connection induced by the Chern connection the Chern sectional curvature of this Hermitian manifold.
Cao, Pandeng, Li, Hongjun
openaire +3 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Group-Quotients with Positive Sectional Curvatures [PDF]
Proceedings of the American Mathematical Society, 1977 Let H be a closed subgroup of compact Lie group G . A necessary and sufficient condition is obtained for the existence of a left-invariant Riemannian metric on G such that the subduced metric on the quotient
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
A New Proof of a Conjecture on Nonpositive Ricci Curved Compact Kähler–Einstein Surfaces
Mathematics, 2018 In an earlier paper, we gave a proof of the conjecture of the pinching of the bisectional curvature mentioned in those two papers of Hong et al. of 1988 and 2011. Moreover, we proved that any compact Kähler–Einstein surface M is a quotient of the complex
Zhuang-Dan Daniel Guan
doaj +1 more source
The values of sectional curvature in indefinite metrics
Commentarii Mathematici Helvetici, 1979 exaly +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source