Results 41 to 50 of about 1,568,392 (257)
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Characterizations of a spacetime of quasi-constant sectional curvature and $\mathcal{F}(\mathcal{R})$-gravity [PDF]
, 2023 The main aim of this article is to investigate a spacetime of quasi-constant sectional curvature. At first, the existence of such a spacetime is established by several examples.
De, Krishnendu +3 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
On sectional and bisectional curvature of the H-umbilical submanifolds
International Journal of Mathematics and Mathematical Sciences, 2002 Let M be an H-umbilical submanifold of an almost Hermitian manifold M˜. Some relations expressing the difference of bisectional and of sectional curvatures of M˜ and of M are obtained.
S. Ianus, G. B. Rizza
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Lie algebras whose Lie groups have negative sectional curvature
Revista Integración, 2022 The aim of this work is to completely describe two families of Lie algebras whose Lie groups have negative sectional curvature. The first family consists of Lie algebras satisfying the following property: given any two vectors in the Lie algebra, the ...
Gil Salgado
doaj
Quasi-projective manifolds with negative holomorphic sectional curvature
, 2022 International audienceLet $(M,\omega)$ be a compact K\"ahler manifold with negative holomorphic sectional curvature. It was proved by Wu-Yau and Tosatti-Yang that $M$ is necessarily projective and has ample canonical bundle.
Guenancia, Henri, Henri Guenancia
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
On 4-Dimensional Lorentzian Manifolds with Pseudo W2-Curvature Tensor in General Relativity
AxiomsThe present paper is devoted to the study of Lorentzian spacetimes endowed with the pseudo W2-curvature tensor. We investigate the geometric and symmetry properties of pseudo W2-flat spacetimes and establish several results concerning their curvature ...
Laltluangkima Chawngthu +3 more
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