Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
The influence of regularization on the geomagnetic core field modeling
地球与行星物理论评Earth's magnetic field is generated through the dynamo action in the liquid outer core. Using observational data from geomagnetic satellites and observatories, we can construct geomagnetic models that describe spatial and temporal variations of the core ...
Juyuan Xu, Yufeng Lin, Keke Zhang
doaj +1 more source
How might magnetic secular variation impact avian philopatry? [PDF]
J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2022 Wynn J +6 more
europepmc +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
The 1990.0 magnetic repeat station survey and normal reference fields for Italy
Annals of Geophysics, 1994 A survey of 116 repeat stations of the Italian Magnetic Network was carried out between 1989 and 1992. We describe the characteristics of the selected network repeat station sites, the characteristics of the measuring equipment, the data reduction ...
G. Dominici +3 more
doaj +1 more source
Evidence of secular variation in Archean crust formation in the Eastern Indian Shield. [PDF]
Sci Rep, 2022 Mandal P.
europepmc +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Geomagnetic secular variation forecast using the NASA GEMS ensemble Kalman filter: A candidate SV model for IGRF-13. [PDF]
Earth Planets Space, 2021 Tangborn A, Kuang W, Sabaka TJ, Yi C.
europepmc +1 more source
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source