Results 71 to 80 of about 13,819 (217)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evidence of secular variation in Archean crust formation in the Eastern Indian Shield. [PDF]

Sci Rep, 2022
Mandal P.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Research on geomagnetic secular variation of China and surrounding areas based on the Geomagnetic Virtual Observatories

Earth and Planetary Physics
The Low Earth Orbit (LEO) geomagnetic satellites provide a large number of high-precision measurements, which are crucial for researching the Secular Variation (SV) of the geomagnetic field.
Jiang Li, Bin Chen
doaj   +1 more source

Geomagnetic secular variation forecast using the NASA GEMS ensemble Kalman filter: A candidate SV model for IGRF-13. [PDF]

Earth Planets Space, 2021
Tangborn A, Kuang W, Sabaka TJ, Yi C.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Sensitivity of the auroral zones to temporal changes in Earth’s internal magnetic field

Journal of Space Weather and Space Climate
It is commonly accepted that the shape and temporal evolution of the auroral zones (here defined as the climatological average of the auroral ovals) are primarily influenced by the dipolar and high-latitude features of the geomagnetic field.
Maffei Stefano, Livermore Philip W., Mound Jonathan E.   +2 more
doaj   +1 more source

Why the 18.6 year tide cannot explain the change of sign observed in j₂ [PDF]

Advances in Geosciences, 2003
Recent studies show a change, starting in 1998, in the behavior of the variation of the dynamical flattening of the Earth (J2), supposed to be constant (secular), and mainly due to the post glacial rebound effect.
F. Deleflie, P. Exertier, G. Metris, P. Berio, O. Laurain, J.-M. Lemoine, R. Biancale   +6 more
doaj  

Archeomagnetic Intensity Spikes: Global or Regional Geomagnetic Field Features?

Frontiers in Earth Science, 2018
Variations of the geomagnetic field prior to direct observations are inferred from archeo- and paleomagnetic experiments. Seemingly unusual variations not seen in the present-day and historical field are of particular interest to constrain the full range
Monika Korte, Catherine G. Constable
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source