Results 121 to 130 of about 1,456,577 (296)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Secure care hospital evaluation of manualised interpersonal art-psychotherapy (SCHEMA): A randomised controlled trial protocol [version 1; peer review: 2 approved]

NIHR Open Research
Background Within the criminal Justice System in the UK one-third of prisoners self-identified as having a learning difficulty and/or disability. This is broadly consistent with formal assessment of the needs of offenders, with 29% of the offender ...
Matthew Franklin, Simon S. Hackett, Katie Aafjes-van Doorn, Paula Foscarini-Craggs, Ania Zubala, Muhammad Riaz, Iain McKinnon, Jennifer Condie, Toni Leigh Harrison, Arman Iranpour, Elizabeth Randell, Sophie Rose, Rachel McNamara   +12 more
doaj   +1 more source

Secure and Trustable Electronic Medical Records Sharing using Blockchain

, 2017
Electronic medical records (EMRs) are critical, highly sensitive private information in healthcare, and need to be frequently shared among peers.
Dubovitskaya, Alevtina, Ryu, Samuel, Schumacher, Michael, Wang, Fusheng, Xu, Zhigang   +4 more
core  

Secure Care in Scotland, a Scoping Study : Developing the Measurement of Outcomes and Sharing Good Practice [PDF]

, 2015
This is a scoping study designed to help identify evidence gaps regarding the outcomes experienced by children and young people placed in secure care in Scotland.
Moodie, Kristina
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Physiology-Aware Rural Ambulance Routing

, 2017
In emergency patient transport from rural medical facility to center tertiary hospital, real-time monitoring of the patient in the ambulance by a physician expert at the tertiary center is crucial.
Berlin Jr., Richard B., Hosseini, Mohammad, Sha, Lui   +2 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Secure doctors – good patient care

Tidsskrift for Den norske legeforening, 2023
openaire   +2 more sources

Family education and family therapy: tools for relational change [PDF]

, 2004
In this paper, I wish to outline the substantive base for family education and family therapy in the necessary interaction of family members to secure uniquely human needs –to create a secure and safe base, to belong, to communicate, to have choices ...
Constable, R. (Robert)
core