Results 51 to 60 of about 1,148,752 (292)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Developer-oriented Web Security by Integrating Secure SDLC into IDEs

Sakarya University Journal of Computer and Information Sciences, 2018
Enterprises and organizations have difficulties to protect their web-based services against cyber-attacks. Due to increasing number of cyber-attacks, critical data including customer data, patient data etc.
Emin İslam Tatlı
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Inculcating secure coding for beginners

, 2016
This paper describes an implementation of a Secure Coding learning package for Undergraduate students in the Kulliyyah of Information and Communication Technology (KICT) at the International Islamic University Malaysia.
A. Aziz, Normaziah, Shamsuddin, Siti Nurul Zulaikha, Hassan, Nur Asnida, Normaziah A. Aziz, Siti Nurul Zulaiha Shamsuddin, Nur Asnida Hassan   +5 more
core   +1 more source

Secure Abstraction with Code Capabilities [PDF]

2013 21st Euromicro International Conference on Parallel, Distributed, and Network-Based Processing, 2013
We propose embedding executable code fragments in cryptographically protected capabilities to enable flexible discretionary access control in cloud-like computing infrastructures. We are developing this as part of a sports analytics application that runs on a federation of public and enterprise clouds. The capability mechanism is implemented completely
Robbert van Renesse, Håvard D. Johansen, Nihar Naigaonkar, Dag Johansen   +3 more
openaire   +4 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tracking the Gaze of Secure Coders: Behavioral Insights into Attention, Transitions, and Training

Journal of Cybersecurity and Privacy
Secure coding is essential, yet the strategies developers use to detect and mitigate flaws are not well understood. We present an eye-tracking-based approach that captures developers’ visual patterns while reading, coding, and applying security tools ...
Daniel Davis, Feng Zhu
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reverse Engineering Environment for Teaching Secure Coding in Java [PDF]

, 2019
Few toolsets for program analysis and Java learning system provide an integrated console, debugger, and reverse engineered visualizer. We present an interactive debugging environment for Java which helps students to understand the secure coding by ...
Lee, Young, Yang, Jeong
core   +1 more source