Results 111 to 120 of about 3,620,659 (295)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

The SECURE collaboration model [PDF]

open access: yes, 2003
The SECURE project has shown how trust can be made computationally tractable while retaining a reasonable connection with human and social notions of trust.
McGettrick, A.   +4 more
core   +2 more sources

Requirements of a Better Secure Program Coding [PDF]

open access: yesInformatică economică, 2012
Secure program coding refers to how manage the risks determined by the security breaches because of the program source code. The papers reviews the best practices must be doing during the software development life cycle for secure software assurance, the
Marius POPA
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Rules of thumb for developing secure software

open access: yes, 2005
This article presents guidelines to develop secure applications in the form of "Do's and Don'ts" applying mostly to the software design level, but also to the implementation level.
Peine, H.
core   +1 more source

Mitigating Software Vulnerabilities through Secure Software Development with a Policy-Driven Waterfall Model

open access: yesJournal of Engineering
For the past few years, software security has become a pressing issue that needs to be addressed during software development. In practice, software security is considered after the deployment of software rather than considered as an initial requirement ...
Shariq Hussain   +6 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Building Secure Software: The Future of Security, Privacy, and Compliance

open access: yes
[EN] In today's rapidly evolving software development landscape, security has become more crucial than ever, with new libraries and frameworks emerging at an unprecedented pace.
Abrahao Gonzales, Silvia Mara   +1 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

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