Results 81 to 90 of about 3,620,659 (295)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Temporal verification in secure group communication system design [PDF]
, 2007 The paper discusses an experience in using a real-time UML/SysML profile and a formal verification toolkit to check a secure group communication system against temporal requirements.
Villemur, Thierry +7 more
core +1 more source
SystemsModern machine learning approaches for vulnerability detection achieve strong performance within specific datasets, yet their reliability degrades under domain shift, limiting their effectiveness for real-world secure software development lifecycle (SDLC)
Samson Quaye +2 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Secure accommodation in Scotland : its role and relationship with 'alternative' services. [PDF]
, 2005 This Scottish Executive funded study of secure accommodation and services which offer an alternative was carried out between November 2002 and 2005, by a research team from the universities of Stirling, Strathclyde and Glasgow.
Hunter, L. +14 more
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Towards Building Secure Software Systems
, 2008 Software security breaches are now very extremely common and a larger percentage is caused by software design defects. Since individuals and organizations now completely depend on software systems for their day-to-day operations, it is then important to ...
O. B. Ajayi +2 more
core
Secure software practices among Malaysian software practitioners: An exploratory study [PDF]
, 2016 Secure software practices is increasingly gaining much importance among software practitioners and researchers due to the rise of computer crimes in the software industry.It has become as one of the determinant factors for producing high quality ...
Baharom, Fauziah +9 more
core +1 more source