Results 51 to 60 of about 5,288,295 (302)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Feature Graph Construction With Static Features for Malware Detection

IET Information Security
Malware can greatly compromise the integrity and trustworthiness of information and is in a constant state of evolution. Existing feature fusion-based detection methods generally overlook the correlation between features.
Binghui Zou, Chunjie Cao, Longjuan Wang, Yinan Cheng, Chenxi Dang, Ying Liu, Jingzhang Sun   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Complexity and Unwinding for Intransitive Noninterference [PDF]

, 2013
The paper considers several definitions of information flow security for intransitive policies from the point of view of the complexity of verifying whether a finite-state system is secure. The results are as follows.
Eggert, Sebastian, Schnoor, Henning, van der Meyden, Ron, Wilke, Thomas   +3 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Security challenges

National security and the future, 2023
The concept of security has expanded beyond the framework of military-political responses. A new paradigm has been established that closely links the concept of security to the risks and challenges arising from dangers such as migration, terrorism, outbreaks of infectious diseases, natural and technological accidents and disasters, organized crime ...
openaire   +3 more sources

Securing By Design [PDF]

, 2011
This article investigates how modern neo-liberal states are 'securing by design' harnessing design to new technologies in order to produce security, safety, and protection.
Adorno, Agamben, Antonelli, Antonelli, Antonelli, Barthes, Baudrillard, Bauman, Bauman, Bratton, Bullivant, Burgess, Cardenas, Collective, Colomina, Connolly, CYNTHIA WEBER, Davis, Davis, Derrida, Doty, Doty, Dunne, Dunne, Dunne, Dunne, Dunne, Dunne, Dunne, Dunne, Eyal, Foucault, Gilles, Hobbes, Johnson, Juncosa, Luke, Luke, Luke, MARK LACY, Nordstrom, Nordstrom, Norman, Ouroussoff, Paterson, Schneier, Schwartz, Singer, Sorkin, Sterling, Sudjic, Thackera, Trüby, Trüby, Virilio, Virilio, Virilio, Virilio, Waltz, Womack, Yelavich   +60 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Smartphone security [PDF]

, 2017
According to eMarketer researchers, the total number of smartphones in active use on the planet exceeded the 2 billion unit in 2016 and amounted up to 2.16 billion against 1.9 billion in 2015 and 1.6 billion devices in 2014.
Mamienko, Sergey, Mieshkov, V.I., Zuyenok, I.І.   +2 more
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source