Results 161 to 170 of about 242,778 (310)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Evaluation of a local ICU sedation guideline on goal-directed administration of sedatives and analgesics

Journal of Pain Research, 2011
Jeremy R DeGrado1, Kevin E Anger1, Paul M Szumita1, Carol D Pierce2, Anthony F Massaro31Department of Pharmacy, 2Department of Nursing, 3Department of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USAPurpose: Sedatives and ...
DeGrado JR, Anger KE, Szumita PM, Pierce CD, Massaro AF   +4 more
doaj  

Effect of Fentanyl on Remimazolam-Induced Sedation in Female Patients Undergoing Hysteroscopic Surgery: A Randomized Controlled Trial [PDF]

Xiao-Dong Huang,1 Lan Xu,2 Cai-Hong Zheng,1 Min-Min Chen,1 Hong-Yan Shou,1 Zhen-Feng Zhou1 1Department of Anesthesiology, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People’s Hospital Qianjiang New City ...
Xu L, Zhou ZF, Chen MM, Shou HY, Zheng CH, Huang XD   +5 more
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Symptom burden profiles and applied medication strategies in the days before and after initiation of palliative sedation in advanced cancer patients: an international prospective multicentre observational study (PALSED). [PDF]

Support Care Cancer
Rijpstra M, Kuip E, Belar A, Surges SM, Adile C, Rojí R, Mercadante S, Radbruch L, Menten J, Centeno C, Hasselaar J, Vissers K.   +11 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Beyond the Ladder: A 10-Domain Cognitive and Operational Toolkit to Humanise and Implement Acute Pain Guidelines at the Bedside

Pain Research and Management
Michele Domenico Spampinato, Sossio Serra, Alessandro Riccardi, Mario Guarino, Claudia Sara Cimmino, Enrico Gandolfo, Fabio De Iaco   +6 more
doaj   +1 more source

Conscious sedation [PDF]

British Dental Journal, 2004
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Remimazolam for Precision Sedation and Anaesthesia in Vulnerable Populations: A Narrative Review of Pharmacological Mechanisms, Stratified Clinical Evidence, and Individualised Perioperative Strategies. [PDF]

Drug Des Devel Ther
Wu G, Zhang J, Li Y, Zhou Y, Wu J, Xiao Z.   +5 more
europepmc   +1 more source