Results 191 to 200 of about 388,946 (338)

Safer sedation for ventilated patients. A new application for etomidate [PDF]

, 1982
D. L. Edbrooke, D. M. Newby, S. J. Mather, Angelina Dixon, B. S. Hebron   +4 more
openalex   +1 more source

Practice patterns and outcomes associated with early sedation depth in mechanically ventilated patients: A systematic review protocol [PDF]

, 2017
Dettmer, Matthew R, Fowler, Susan A, Fuller, Brian M, Roberts, Brian W, Stephens, Robert J   +4 more
core   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

‘Targeting’ sedation:the lived experience of the intensive care nurse [PDF]

, 2013
Attinasi, Augustes, Beard, British Broadcasting Corporation News, British Medical Association, Centers for Disease Control and Prevention, Dodek, Dotson, Dunn, Endacott, Finlay, Finlay, Fontana, Girard, Hahm, Heidegger, Institute for Healthcare Improvement (IHI), Jackson, Johnson, Jones, Jootun, Koch, Kress, McEvoy, McGrath, Mehta, Miller, NHS Quality Improvement Scotland, O'Connor, Patel, Resar, Rowe, Royal College of Nursing, Sandelowski, Saunders, Shehabi, Strøm, Tanios, Thompson, Topping, Van der Zalm, Van Manen, Vivilaki, Vouzavali, World Health Organisation (WHO), World Health Organisation (WHO), Wunsch   +46 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

A Case Series of the Use of Intranasal Dexmedetomidine for Procedural Sedation in the Pediatric Emergency Department. [PDF]

J Pediatr Pharmacol Ther
Gregory H, Bethel C, Anton G, Whitaker M, Zargham S.   +4 more
europepmc   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

What Every Intensivist Should Know About Remimazolam. [PDF]

Indian J Crit Care Med
Mathur R, Chittoria K, Sharma A, Goyal S, Kothari N.   +4 more
europepmc   +1 more source

Hazards during Anæsthesia or Sedation for Dental Procedures [Abridged]

, 1971
T.E.J. HEALY, M D Vickers
openalex   +1 more source