Results 211 to 220 of about 412,312 (339)

Safety of midazolam-propofol combination for sedation in pediatric patients undergoing gastrointestinal endoscopy

, 2019
Sami Eksert, Necati Balamtekın, Mustafa Gülgün, Mehmet Ince   +3 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Comparison of Remimazolam and Midazolam for Sedation During Endoscopic Retrograde Cholangiopancreatography-Related Procedures. [PDF]

DEN Open
Tanisaka Y, Ryozawa S, Ito S, Mizuide M, Fujita A, Watanabe R, Hamamura R, Matsuno Y.   +7 more
europepmc   +1 more source

Tu1062 UNACCOMPANIED RIDESHARE AFTER PROPOFOL SEDATION: AN “UBER” SOLUTION TO NEEDING A “LYFT” AFTER ENDOSCOPY? [PDF]

, 2018
Michael A. Chang, Syed M. Abbas Fehmi, Denise Kalmaz, Thomas J. Savides   +3 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Barriers to Changing Sedation Practice for Patients Undergoing Mechanical Ventilation on the Intensive Care Unit: A Qualitative Interview Study of Clinical Staff. [PDF]

Nurs Crit Care
Richards ND, Bekker HL, Howell SJ.
europepmc   +1 more source

Deep brain stimulation under general anaesthesia for Parkinson's disease: A retrospective evaluation of perioperative events and anaesthetic management after switching away from conscious sedation [PDF]

Marta García-Orellana, Felipe Maldonado, Paola Hurtado, Gabriel Pujol Fontrodona, Pedro Roldán, Alejandra Mosteiro, Jordi Rumià, Almudena Sánchez‐Gómez, Nicolás de Riva, Neus Fàbregas, Isabel Gracia, J. Tercero, Eugènia Pujol‐Ayach, R. Valero   +13 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Daily Sedation Interruption Versus Continuous Sedation in Mechanically Ventilated Pediatric Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Cureus
Alhag MH, Awami HM, Samman L, Alshreef BS, Ahmed A, Beda MA, Abu Ayish A, Hussein SK, Mansoor S, Alkhulaidi R, Ashraf T, Marzouk S, Mulla RM, Aloufi SA.   +13 more
europepmc   +1 more source

Assessment of Patient-Reported Outcome and Sedation-Agitation Score in Critically Ill Patients [PDF]

, 2018
Meng-Ni Ho
openalex