Results 101 to 110 of about 100,774 (304)

Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization

open access: yes, 2008
We evaluated changes in the binding properties of sedative and non-sedative histamine H1–receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells.
Hiroshi Komazaki   +4 more
core   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

4-Hydroxybenzyl alcohol derivatives and their sedative–hypnotic activities

open access: yes, 2018
2FHBA, a derivative of HBA, exerts sedative and hypnotic effects through the serotonergic and GABAergic systems.
Yan Zhao   +6 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Propofol‐alone sedative efficacy in observational biliopancreatic endoscopic ultrasound

open access: yesDEN Open
Objectives Appropriate sedative and analgesic selection is essential to reduce patient discomfort and body movement to safely conduct endoscopic ultrasonography (EUS).
Hisaki Kato   +8 more
doaj   +1 more source

Medicinal plants for the "nerves": a review of ethnobotanical studies carried out in South Brazil

open access: yesActa Botânica Brasílica
Among the medicinal purposes for which plants have been used is the treatment of “nerves". The objective of this study was to search for species of plants used in the state of Rio Grande do Sul (South Brazil) for the relief of symptoms related to central
Andressa Verdum Gross   +4 more
doaj   +1 more source

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators

open access: yesMolecules, 2018
GABA(A) receptors are ligand-gated ion channels consisting of five subunits from eight subfamilies, each assembled in four hydrophobic transmembrane domains.
Serhat Sezai Çiçek
doaj   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu   +7 more
wiley   +1 more source

Prophylactic effect of compression stockings for elevated D‐dimer levels following endoscopic submucosal dissection

open access: yesDEN Open
Objectives A relationship between endoscopic submucosal dissection (ESD) and deep vein thrombosis has been recognized. We previously reported that a high corrected midazolam dose (total midazolam dose/initial dose of midazolam used to induce sedation) is
Fumito Harada   +15 more
doaj   +1 more source

The concept of ’Musa-pelo and the medicinal use of shrubby legumes (Fabaceae) in Lesotho

open access: yesBothalia: African Biodiversity & Conservation, 2007
In the Kingdom of Lesotho, 20 plant species are commonly known as  'Musa-pelo. The term literally means ‘the one who brings back or tums around the heart’.
A. Moteetee, B-E. van Wyk
doaj   +1 more source

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